Browsing by Author "Acharya, Bipul Ranjan"

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Deuterium oxide stabilizes conformation of tubulin: A biophysical and biochemical study

Das, Amlan; Sinha, Sharmistha; Acharya, Bipul Ranjan; Paul, Pinaki; Bhattacharyya, Bhabatarak; Chakrabarti, Gopal (KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY, 2008-01-31)

The present study was aimed to elucidate the mechanism of stabilization of tubulin by deuterium oxide (D2O). Rate of decrease of tryptophan fluorescence during aging of tubulin at 4 degrees C and 37 degrees C was significantly ...
Genistein Arrests Cell Cycle Progression of A549 Cells at the G2/M Phase and Depolymerizes Interphase Microtubules through Binding to a Unique Site of Tubulin

Mukherjee, Sumita; Acharya, Bipul Ranjan; Bhattacharyya, Bhabatarak; Chakrabarti, Gopal (AMER CHEMICAL SOC, 2010-03-02)

Genistein (40,5,7-trihydroxyisoflavone), an isoflavone, is a major constituent of soyfoods. It has potential antiproliferative activity against several tumor types. We have examined the effect of genistein on cellular ...
The natural naphthoquinone plumbagin exhibits antiproliferative activity and disrupts the microtubule network through tubulin binding

Acharya, Bipul Ranjan; Bhattacharyya, Bhabatarak; Chakrabarti, Gopal (AMER CHEMICAL SOC, 2008-07-29)

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), a naphthoquinone isolated from the roots of Plumbaginaceae plants, has potential antiproliferative activity against several tumor types. We have examined the effects of ...