Dr. Debjani Roy
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Recent Submissions
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Homology modeling of allergenic cyclophilins: IgE-binding site and structural basis of cross-reactivity
(ACADEMIC PRESS, 2003-07-25)Cross-reactivity among allergens is of considerable scientific as well as clinical interest. Proteins belonging to the allergenic cyclophilin family share a high degree of sequence homology and are cross-reactive. Until ... -
Sequence divergence of Entamoeba histolytica tubulin is responsible for its altered tertiary structure
(ACADEMIC PRESS, 2004-07-02)Atypical microtubular structures of the protozoan parasite Entamoeba histolytica (Eh) have been attributed to amino acid sequence divergence of Eh tubulin. To investigate if this sequence divergence leads to significant ... -
Small cationic protein from a marine turtle has beta-defensin-like fold and antibacterial and antiviral activity
(WILEY-LISS, 2006-08-01)Egg white of marine turtle Caretta caretta contains a small cationic protein but lacks lysozyme. The protein was sequenced by a combination of sequential Edman degradation, carboxypeptidase digestion, nuclear magnetic ... -
Structural features of a cold-adapted Alaskan bacterial lipase
(ADENINE, 2007-04)The three dimensional model of cold-adapted Alaskan psychrotroph Pseudomonas species (Strain B11-1) lipase has been constructed by homology modeling based on the crystal structure of acetyl esterase from Rhodococcus species ... -
An insight into the molecular basis of salt tolerance of L-myo-inositol 1-P synthase (PcINO1) from Porteresia coarctata (Roxb.) Tateoka, a halophytic wild rice
(AMER SOC PLANT BIOLOGISTS, 2006-04)The molecular basis of salt tolerance of L myo-inositol 1-P synthase (MIPS; EC 5.5.1.4) from Porteresia coarctata (Roxb.) Tateoka (PcINO1, AF412340) earlier reported from this laboratory, has been analyzed by in vitro ... -
Homology modeling of a transcriptional regulator SoxR of the lithotrophic sulfur oxidation (sox) operon in α-proteobacteria
(ADENINE PRESS, 2005-04)Microbial oxidation of reduced inorganic sulfur compounds in the environment is one of the major reactions of the global sulfur cycle mediated by phylogenetically diverse prokaryotes. The sulfur oxidizing gene cluster (sox) ... -
Structural considerations for designing adenosine analogs as selective inhibitors of Trichomonas sp. glyceraldehyde-3- phosphate dehydrogenase.
(IOS Press, 2007)Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of pathogenic protozoa Trichomonas vaginalis (TvGAPDH) is an attractive drug target since this parasite lacks functional citric acid cycle and is dependent solely on glycolysis ... -
Differential colchicine-binding across eukaryotic families: The role of highly conserved Pro268 beta and Ala248 beta residues in animal tubulin
(ELSEVIER, 2007-10-30)Colchicine-tubulin interaction, responsible for the disruption of microtubule formation, has immense pharmacological importance but is poorly understood in terms of its biological significance. The interaction is characterized ... -
Computational study of glyceraldehyde-3-phosphate dehydrogenase of Entamoeba histolytica: Implications for structure-based drug design
(ADENINE, 2007-08)Glyceraldehyde-3 -phosphate dehydrogenase (GAPDH) of the pathogenic protozoa Entamoeba histolytica (Eh) is a major glycolytic enzyme and an attractive drug target since this parasite lacks a functional citric acid cycle ... -
Temperature-induced unfolding pathway of a type III antifreeze protein: Insight from molecular dynamics simulation
(ELSEVIER, 2008-08)Molecular dynamics simulations of the temperature-induced unfolding reaction of a cold-adapted type III antifreeze protein (AFPIII) from the Antarctic eelpout Lycodichthys dearborni have been carried out for 10 ns each at ... -
Structural study of biologically significant ligands with major birch pollen allergen Betv1 by docking and molecular dynamics simulation.
(Biomedical Informatics, 2010-01-24)The major birch pollen allergen, Betv1 of Betula verrucosa is the main causative agent of birch pollen allergy in humans. Betv1 is capable of binding several physiological ligands including fatty acids, flavones, cytokinins ... -
Comparative structural studies of psychrophilic and mesophilic protein homologues by molecular dynamics simulation
(ELSEVIER, 2009-06)Comparative molecular dynamics simulations of psychrophilic type III antifreeze protein from the North-Atlantic ocean-pout Macrozoarces americanus and its corresponding mesophilic counterpart, the antifreeze-like domain ... -
Codon usage and gene expression pattern of Stenotrophomonas maltophilia R551-3 for pathogenic mode of living
(ACADEMIC PRESS, 2009-12-11)Stenotrophomonas maltophilia strain R551-3 is a multiple-antibiotic-resistant opportunistic human pathogen involved in nosocomial infections. It has a widely distributed GC-rich (>66%) genome. Analysis of differential ... -
Structural study of carboxylesterase from hyperthermophilic bacteria Geobacillus stearothermophilus by molecular dynamics simulation
(ELSEVIER SCIENCE, 2010-06)Carboxylesterases are ubiquitous enzymes with important physiological, industrial and medical applications such as synthesis and hydrolysis of stereo specific compounds, including the metabolic processing of drugs, and ...
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