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An expedient synthesis of novel 2-substituted thiazolo[4,5-f]isoquinolines/quinolines and benzo[1,2-d:4,3-d ']bisthiazoles and their potential as inhibitors of COX-1 and COX-2

dc.contributor.authorChakrabarty, Manas
dc.contributor.authorMukherji, Ajanta
dc.contributor.authorKarmakar, Sulakshana
dc.contributor.authorMukherjee, Ratna
dc.contributor.authorNagai, Kenichiro
dc.contributor.authorGeronikaki, Athina
dc.contributor.authorEleni, Pitta
dc.date.accessioned2012-11-12T07:23:15Z
dc.date.available2012-11-12T07:23:15Z
dc.date.issued2010-11-07
dc.identifierFOR ACCESS / DOWNLOAD PROBLEM -- PLEASE CONTACT LIBRARIAN, BOSE INSTITUTE, akc@bic.boseinst.ernet.inen_US
dc.identifier.citationChakrabarty M, Mukherji A, Karmakar S, Mukherjee R, Nagai K, Geronikaki A and Eleni Pen_US
dc.identifier.issn1551-7004
dc.identifier.uri1. Full Text Link ->en_US
dc.identifier.urihttp://quod.lib.umich.edu/cgi/p/pod/dod-idx/expedient-synthesis-of-novel-2-substituted-thiazolo45.pdf?c=ark;idno=5550190.0011.b22en_US
dc.identifier.uri=================================================en_US
dc.identifier.uri2. Scopus : Citation Link ->en_US
dc.identifier.urihttp://www.scopus.com/record/display.url?eid=2-s2.0-78650321129&origin=resultslist&sort=plf-f&src=s&st1=Chakrabarty%2cM&nlo=&nlr=&nls=&sid=0ZBjvr-79NXz18j3GroULoM%3a510&sot=b&sdt=sisr&sl=26&s=AUTHOR-NAME%28Chakrabarty%2cM%29&ref=%28An+expedient+synthesis+of+novel%29&relpos=0&relpos=0&searchTerm=(AUTHOR-NAME(Chakrabarty,M)) AND (An expedient synthesis of novel)en_US
dc.description.abstractAn efficient, general synthesis of 2-substituted thiazolo[4,5-f]isoquinolines, thiazolo[4,5-f]quinolines and benzo[1,2-d:4,3-d']bisthiazoles has been accomplished from 5-nitroisoquinoline/quinoline and 6-nitrobenzothiazole, respectively, and all the products have been thoroughly identified spectroscopically (IR, (1)H and (13)C NMR, LR/HR EI/FAB/ESI-MS). The synthesis of thiazolo[4,5-f]isoquinolines constitutes the first synthesis of this class of heteroarenes. Eighteen compounds, covering all three types, were screened for inhibition of COX-1 and COX-2, and some of them showed moderate activities.en_US
dc.language.isoenen_US
dc.publisherARKAT USAen_US
dc.subjectBenzobisthiazolesen_US
dc.subjectCox-inhibitionen_US
dc.subjectCox-inhibitionen_US
dc.subjectThiazoloquinolinesen_US
dc.subjectWOS:000284104800022en_US
dc.titleAn expedient synthesis of novel 2-substituted thiazolo[4,5-f]isoquinolines/quinolines and benzo[1,2-d:4,3-d ']bisthiazoles and their potential as inhibitors of COX-1 and COX-2en_US
dc.title.alternativeARKIVOCen_US
dc.typeArticleen_US


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