Subrata Majumder
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Regulation of impaired protein kinase C signaling by chemokines in murine macrophages during visceral leishmaniasis
(AMER SOC MICROBIOLOGY, 2005-12)The protein kinase C (PKC) family regulates macrophage function involved in host defense against infection. In the case of Leishmania donovani infection, the impairment of PKC-mediated signaling is one of the crucial events ... -
Specific and randomly derived immunoactive peptide mimotopes of mycobacterial antigens
(AMER SOC MICROBIOLOGY, 2006-10)The mycobacterial cell surface contains complex nonprotein antigens that are highly immunoactive in nature. However, these antigens are chemically heterogeneous and structurally complex, thereby limiting their applications. ... -
An unusual pro-inflammatory role of interleukin-10 induced by arabinosylated lipoarabinomannan in murine peritoneal macrophages
(SPRINGER, 2006-12)Various species of Mycobacteria produce a major cell wall-associated lipoglycan, called Lipoarabinomannan (LAM), which is involved in the virulence of Mycobacterial species. In this study, we tried to establish the role ... -
Induction of host protective th1 immune response by chemokines in Leishmania donovani-infected BALB/c mice
(BLACKWELL, 2007-12)The resolution from leishmanial infection is dependent on the coordinated interactions between the components of the cell mediated immune system and the activation of T-cell population into appropriate cytokine production ... -
Immunomodulatory role of arabinosylated lipoarabinomannan on Leishmania donovani infected murine macrophages
(NATL INST SCIENCE COMMUNICATION, 2007-10)Arabinosylated lipoarabinomannan (Ara-LAM), a surface glycolipid antigen isolated from avirulent Mycobacterium smegmatis is involved in modulation of host cell signaling. In this study, we investigated Ara-LAM-mediated ... -
Leishmania donovani-induced ceramide as the key mediator of Akt dephosphorylation in murine macrophages: Role of protein kinase C zeta and phosphatase
(AMER SOC MICROBIOLOGY, 2007-05)Leishmania donovani is an intracellular protozoan parasite that impairs the host macrophage immune response to render it suitable for its survival and establishment. L. donovani-induced immunosuppression and alteration of ... -
Anti-inflammatory effect of allylpyrocatechol in LPS-induced macrophages is mediated by suppression of iNOS and COX-2 via the NF-kappa B pathway
(ELSEVIER SCIENCE BV, 2008-09)The crude ethanol extract of Piper betle leaf is reported to possess anti-inflammatory activity which has been suggested to be mediated by allylpyrocatechol (APC). In the present study, we have demonstrated the anti-inflammatory ... -
Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function
(NATURE PUBLISHING GROUP, 2009-03)CD40, a costimulatory molecule expressed on macrophages, induces expression of interleukin 12 (IL-12) in uninfected macrophages and IL-10 in macrophages infected with Leishmania major. IL-12 suppresses, whereas IL-10 ... -
Arabinosylated lipoarabinomannan modulates the impaired cell mediated immune response in Mycobacterium tuberculosis H37Rv infected C57BL/6 mice
(ELSEVIER SCIENCE BV, 2008-04)Mycobacterium tuberculosis is a facultative intracellular pathogen that flourishes inside the host macrophages. This organism has the ability to deactivate the cell-mediated immune responses involving the down-regulation ... -
Restoration of impaired free radical generation and proinflammatory cytokines by MCP-1 in mycobacterial pathogenesis
(BLACKWELL PUBLISHING, 2008-04)Mycobacterium tuberculosis exerts its pathogenic effects mainly via its cell wall glycolipid called Mannosylated Lipoarabinomannan (Man-LAM), which subverts the cellular inflammatory responses by the suppression of superoxide ... -
Potentiation by cigarette smoke of macrophage function against Leishmania donovani infection
(BIRKHAUSER VERLAG AG, 2009-01)Cigarette smoke is able to induce the generation of reactive oxygen species and pro-inflammatory cytokines, which are mediators of macrophage function and therefore, we have investigated the ability of cigarette smoke to ... -
In Vitro Nicotine-Induced Oxidative Stress in Mice Peritoneal Macrophages: A Dose-Dependent Approach
(TAYLOR & FRANCIS INC, 2009-02)The immune cells use reactive oxygen species (ROS) for carrying out their normal functions while an excess amount of ROS can attack cellular components that lead to cell damage. In the present study, peritoneal macrophages ... -
A novel approach to regulate experimental visceral leishmaniasis in murine macrophages using CCR5 siRNA
(BLACKWELL PUBLISHING, 2008-04)Early infection with Leishmania donovani during visceral leishmaniasis (VL) results in the enhanced expression of C-C chemokine receptor 5 (CCR5) in macrophages. CCR5 expression at different time points of infection revealed ... -
Eugenol protects nicotine-induced superoxide mediated oxidative damage in murine peritoneal macrophages in vitro
(ELSEVIER SCIENCE, 2009-11-25)The present work is aimed at evaluating the protective effect of eugenol against in vitro nicotine-induced toxicity in murine peritoneal macrophages, compared with N-acetylcysteine. Eugenol was isolated from Ocimum gratissimum ... -
Anti-IL-10 mAb protection against experimental visceral leishmaniasis via induction of Th1 cytokines and nitric oxide
(NATL INST SCIENCE COMMUNICATION, 2009-06)Visceral leishmaniasis is characterized by severe immune suppression of the host. This suppression of the host immune system is primarily mediated by the immunosuppressive cytokine Interleukin-10 (IL-10), whose levels are ... -
CXC Chemokine-Mediated Protection against Visceral Leishmaniasis: Involvement of the Proinflammatory Response
(UNIV CHICAGO PRESS, 2009-10-15)Visceral leishmaniasis, caused by the protozoan parasite Leishmania donovani, is characterized by the loss of ability of the host to generate an effective immune response. In the present study, the comparative potential ... -
Amphotericin B regulates the host immune response in visceral leishmaniasis: reciprocal regulation of protein kinase C isoforms.
(W B SAUNDERS, 2010-07)OBJECTIVES: Treatment of visceral leishmaniasis (VL) is marked by the failure of pentavalent antimonials which has brought amphotericin B (AmpB) to the forefront. In this study we have focused on signaling pathway ... -
Alteration of immune functions and Th1/Th2 cytokine balance in nicotine-induced murine macrophages: Immunomodulatory role of eugenol and N-acetylcysteine
(ELSEVIER SCIENCE, 2011-04)The aim of this study was to evaluate the immune functions by nicotine-induced murine peritoneal macrophages, and Th1/Th2 cytokine balance in it, and concurrently to establish the immunomodulatory role of eugenol, and ... -
Mannosylated solid lipid nanoparticles as vectors for site-specific delivery of an anti-cancer drug
(ELSEVIER SCIENCE, 2010-12-20)The purpose of the present study was to investigate the tumor targeting potential of surface tailored solid lipid nanoparticles (SLNs) loaded with an anti-cancer drug doxorubicin HCl (DOX). DOX encapsulating SLNs were ... -
Berberine Chloride Mediates Its Anti-Leishmanial Activity via Differential Regulation of the Mitogen Activated Protein Kinase Pathway in Macrophages
(PUBLIC LIBRARY SCIENCE, 2011-04-05)Background: A complex interplay between Leishmania and macrophages influences parasite survival and necessitates disruption of signaling molecules, eventually resulting in impairment of macrophage function. In this study, ...
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