Tanya Das
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The Bcl-2 transgene protects T cells from renal cell carcinoma-mediated apoptosis
(AMER ASSOC CANCER RESEARCH, 2003-08-15)Purpose: Tumors induce T-cell apoptosis as a mechanism. of inhibiting antitumor immunity. Using coculture experiments, it has been shown that tumor lines stimulate T-cell apoptosis by a pathway involving a mitochondrial ... -
Over-expressed IgG2 antibodies against O-acetylated sialoglycoconjugates incapable of proper effector functioning in childhood acute lymphoblastic leukemia
(OXFORD UNIV PRESS, 2005-02)Earlier studies have demonstrated an over-expression of 9-O-acetylated sialoglycoconjugates (9-OAcSGs) on lymphoblasts, concomitant with high titers of anti-9-OAcSGs in childhood acute lymphoblastic leukemia (ALL). The ... -
Tumor-induced dysfunction in T lymphocytes: increased sensitivity to apoptosis
(SPRINGER, 2004-09) -
Effect of renal cell carcinomas on the development of type 1 T-cell responses( Conference Paper )
(AMER ASSOC CANCER RESEARCH, 2004-09-15)Purpose: We reported that in renal cell carcinoma patients with active disease, T-cell reactions to the tumor-associated antigens MAGE-6 and EphA2 are highly skewed toward T(H)2-type cytokine responses [interleukin (IL) ... -
Failure in peripheral immuno-surveillance due to thymic atrophy: Importance of thymocyte maturation and apoptosis in adult tumor-bearer(M-T-2005)
(PERGAMON-ELSEVIER SCIENCE LTD, 2005-10-07)Tumor-induced immunosuppression often leads to failure in cancer therapy. Here, in an attempt to understand the course of tumor-dependent immunosuppression in young adult murine model, we found that in Ehrlich's ascites ... -
Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin
(ELSEVIER SCI LTD, 2005)Background: The true therapeutic benefit of the use of natural products, especially acceptable dietary components such as curcumin, which can spare the normal cells and boost host immunity, has opened new horizons in cancer ... -
Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G(2) phase of cell cycle in a p53-dependent manner
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2005-05-20)Curcumin (diferuloylmethane) is known to induce apoptosis in tumor cells. In asynchronous cultures, with time-lapse video-micrography in combination with quantitative fluorescence microscopy, we have demonstrated that ... -
Overcoming drug-resistant cancer by a newly developed copper chelate through host-protective cytokine-mediated apoptosis
(AMER ASSOC CANCER RESEARCH, 2006-07-15)Purpose: Previously, we have synthesized and characterized a novel Cu(II) complex, copper N-(2-hydroxyacetophenone) glycinate (CuNG). Herein, we have determined the efficacy of CuNG in overcoming multidrug-resistant cancer ... -
Tumor-induced oxidative stress perturbs nuclear factorr-kappa B activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: Protection by curcumin
(AMER ASSOC CANCER RESEARCH, 2007-01-01)Cancer patients often exhibit loss of proper cell-mediated immunity and reduced effector T-cell population in the circulation. Thymus is a major site of T-cell maturation, and tumors induce thymic atrophy to evade cellular ... -
Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2007-06-01)Patients with advanced cancer exhibit multifaceted defects in their immune capacity, which are likely to contribute to an increased susceptibility to infections and disease progression. We demonstrated earlier that curcumin ... -
Renal cell carcinoma tumors induce T cell apoptosis through receptor-dependent and receptor-independent pathways(M-T-ANR-2007-08)
(2008-04-01)Tumors can promote their own progressive growth by inducing T cell apoptosis. Though previous studies suggested that tumor-mediated T cell killing is receptor dependent, we recently showed that tumor gangliosides also ... -
Multifocal signal modulation therapy of cancer: ancient weapon, modern targets
(SPRINGER, 2010-03)Although safe in most cases, ancient treatments are ignored because neither their active components nor their molecular targets are well defined. This is not the case, however, with curcumin, a yellow-pigment substance and ... -
Theaflavins retard human breast cancer cell migration by inhibiting NF-kappa B via p53-ROS cross-talk
(ELSEVIER SCIENCE, 2010-01-04)The present study demonstrates that theaflavins exploit p53 to impede metastasis in human breast cancer cells. Our data suggest that p53-dependent reactive oxygen species (ROS) induce p53-phosphorylation via p38MAPK in a ... -
Tumor-Shed PGE(2) Impairs IL2R gamma c-Signaling to Inhibit CD4(+) T Cell Survival: Regulation by Theaflavins
(PUBLIC LIBRARY SCIENCE, 2009-10-08)Background: Many tumors are associated with decreased cellular immunity and elevated levels of prostaglandin E2 (PGE2), a known inhibitor of CD4+ T cell activation and inducer of type-2 cytokine bias. However, the role of ... -
Gain of Cellular Adaptation Due to Prolonged p53 Impairment Leads to Functional Switchover from p53 to p73 during DNA Damage in Acute Myeloid Leukemia Cells
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2010-10-22)Although it has been well established that spermatogenic cells undergo apoptosis when treated with ethanol, the molecular mechanisms behind it remain to be investigated. Adult male mice were given intra-peritoneal injection ... -
Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts
(NATURE PUBLISHING GROUP, 2010-07-01)Immune dysfunction is well documented during tumor progression and likely contributes to tumor immune evasion. CD8(+) cytotoxic T lymphocytes (CTLs) are involved in antigen-specific tumor destruction and CD4(+) T cells are ...
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