Synthesis of Tri- and Disaccharide Fragments Related to the O-Antigen of Enteropathogenic Escherichia Coli O158

Abstract

Chemical synthesis of a tri- and a disaccharide related to the O-antigen of enteropathogenic E. coli O158 was achieved in high yield. In the disaccharide (2), one D-galactosamine unit is present in 1,2-cis-linked and the other is in the trans-orientation, and both of them were prepared from the same intermediate by tuning the reaction solvent. Yields were considerably high in all steps.