Total synthesis of a unique tetrasaccharide present in the human clotting factor IX and mammalian Notch 1 receptor

Abstract

The Synthesis Of a unique tetrasaccharide linked to the serine 61 of human clotting factor IX through an alpha-L-fucose residue has been achieved for the first time in excellent yield. All glycosylation and protecting group manipulation steps are high yielding and reproducible for a scale-Lip preparation. A sequential glycosylation strategy has been used to assemble suitably protected monosaccharide synthons for the preparation of the target tetrasaccharide.