Mild deprotection of tert-butyl carbamates of NH-heteroarenes under basic conditions

Abstract

Aqueous methanolic potassium carbonate under reflux has been demonstrated to be a highly effective deprotective agent for the tert -butyl carbamates of indoles, indazoles, carbazole, thiazoloindole, and pyrrole. The method is a mild one and is particularly expeditious for NH-heteroarenes bearing electron-withdrawing groups.