DSpace at Bose Institute: Recent submissions
Now showing items 1121-1140 of 2749
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Viscosity divergence and gelation
(PERGAMON-ELSEVIER SCIENCE LTD, 2005-12-01)A new model of gelation is presented in which the viscosity is observed to diverge without the introduction of shear elasticity when a critical concentration of suspended particles is reached. This viscosity divergence ... -
Ultraviolet-visible-near infrared and mid-Fourier transform infrared spectroscopic studies of intermolecular interaction in cholesteryl oleyl carbonate in mesophases
(AMER INST PHYSICS, 2006-03-28)Ultraviolet-visible-near infrared (UV-Vis-NIR) and Fourier transform infrared (FTIR) spectroscopic studies are presented of molecular association between like molecules of cholesteryl oleyl carbonate, each containing ... -
The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties
(JOHN WILEY & SONS LTD, 2006-07-01)The aim of this study was to investigate the hepatoprotective action of the protein fraction of Phyllanthus niruri against acetaminophen (APAP) hepatotoxicity. The partially purified protein fraction of P. niruri was ... -
A 43-kDa protein from the leaves of the herb Cajanus indicus L. modulates chloroform induced hepatotoxicity in vitro
(Informa Healthcare., 2006-12-01)A 43-kDa protein isolated from the leaves of the herb Cajanus indicus L. has been shown to possess a protective role against drug- and toxin- induced hepatotoxicity both in vivo and in vitro . The current study was conducted ... -
The B-ring substituent at C-7 of colchicine and the alpha-C-terminus of tubulin communicate through the "tail-body" interaction
(WILEY-LISS, 2004-11-15)The carboxy terminals of alphabeta-tubulins are flexible regions rich in acidic amino acid residues that play an inhibitory role in the polymerization of tubulin to microtubules. We have shown that the binding of colchicine ... -
Sulfonamide drugs binding to the colchicine site of tubulin: Thermodynamic analysis of the drug-tubulin interactions by isothermal titration calorimetry
(AMER CHEMICAL SOC, 2005-01-27)The discovery of several sulfonamide drugs paved the way toward the synthesis of 6 (N-12-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide: E7010) and 7 (N-(3fluoro-4-methoxyphenyl)pentafluorobenzenesulfonamide, ... -
-NH-dansyl isocolchicine exhibits a significantly improved tubulin-binding affinity and microtubule inhibition in comparison to isocolchicine by binding tubulin through its A and B rings
(AMER CHEMICAL SOC, 2005-03-08)Structure-activity relationship studies have established that the A and C rings of colchicine comprise the minimum structural feature necessary for high affinity drug-tubulin binding. Thus, colchicine acts as a bifunctional ... -
Over-expressed IgG2 antibodies against O-acetylated sialoglycoconjugates incapable of proper effector functioning in childhood acute lymphoblastic leukemia
(OXFORD UNIV PRESS, 2005-02)Earlier studies have demonstrated an over-expression of 9-O-acetylated sialoglycoconjugates (9-OAcSGs) on lymphoblasts, concomitant with high titers of anti-9-OAcSGs in childhood acute lymphoblastic leukemia (ALL). The ... -
Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo
(ELSEVIER, 2006-10-01)Nimesulide (NIM), an atypical non-steroidal anti-inflammatory drug (NSAID) is also used as analgesic. In the present study, we evaluated its effect on the prooxidant-antioxidant system of liver and the hepatoprotective ... -
Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders
(ELSEVIER, 2006-09-01)Background: Carbon tetrachloride (CCI4) is a well-known hepatotoxin and exposure to this chemical is known to induce oxidative stress and causes liver injury by the formation of free radicals. Acute and chronic renal damage ... -
Protein isolate from the herb, Phyllanthus niruri, protects liver from acetaminophen induced toxicity
(ELSEVIER, 2006-01-01)Phyllanthus niruri L. (Euphorbiaceae) is a well-known hepatoprotective herbal plant. The aim of this study was to investigate the hepatoprotective action of the protein isolate of Phyllanthus niruri (P. niruri) against ... -
Black tea protects thymocytes in tumor-bearing animals by differential regulation of intracellular ROS in tumor cells and thymocytes
(BEGELL HOUSE INC, 2005)The accumulated in vitro evidence indicates that many tumors induce T-cell apoptosis as a mechanism of inhibiting antitumor activity. This downregulation of cell-mediated immune functions occurring at the late stages of ... -
Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress.
(ELSEVIER, 2006-05-01)Present study was conducted to evaluate the role of a protein fraction (PI, protein isolate) of the herb, Phyllanthus niruri (P. niruri) against nimesulide-induced oxidative stress in vivo using a murine model. Mice were ... -
Tumor-induced dysfunction in T lymphocytes: increased sensitivity to apoptosis
(SPRINGER, 2004-09) -
A 43 kDa protein from the herb Cajanus indicus L. protects thioacetamide induced cytotoxicity in hepatocytes
(PERGAMON-ELSEVIER SCIENCE LTD, 2006-08-01)The aim of this study was to investigate the role of a hepatoprotective protein isolated from the herb Cajanus indicus L. on thioacetamide (TAA) induced toxicity in isolated mouse hepatocytes. In vitro cell viability, ... -
Effect of renal cell carcinomas on the development of type 1 T-cell responses( Conference Paper )
(AMER ASSOC CANCER RESEARCH, 2004-09-15)Purpose: We reported that in renal cell carcinoma patients with active disease, T-cell reactions to the tumor-associated antigens MAGE-6 and EphA2 are highly skewed toward T(H)2-type cytokine responses [interleukin (IL) ... -
Purification and characterization of a 43 kD hepatoprotective protein from the herb Cajanus indicus L.
(SPRINGER, 2006-09-01)Cajanus indicus L, a herb, is popularly known for its hepatoprotective activity. Aqueous extract of the leaves of this plant contains hepatoprotective and hepatostimulatory molecule(s). Present study was aimed to isolate, ... -
Protective role of Phyllanthus niruri against nimesulide induced hepatic damage
(ELSEVIER, 2007)Present study aimed to evaluate the protective role of the aqueous extract of Phyllanthus niruri (P. niruri) against nimesulide-induced hepatic disorder in mice by determining levels of glutamate oxaloacetate transaminase ... -
Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio
(ELSEVIER SCI IRELAND LTD, 2004-06-25)It is known that cancer is associated with altered immune function. We demonstrated earlier that black tea inhibits tumor growth in a dose-dependent manner. Here, we report that apoptosis was the cause of immunocyte death ... -
Protein isolate from the herb Phyllanthus niruri modulates carbon tetrachloride-induced cytotoxicity in hepatocytes
(TAYLOR & FRANCIS INC, 2007-01-01)Phyllanthus niruri is a well-known hepatoprotective herbal plant. In the present study, hepatoprotective potential of the protein isolate of P. niruri was investigated against carbon tetrachloride (CCl4)-induced hepatoxicity ...