DSpace at Bose Institute: Recent submissions
Now showing items 1781-1800 of 2749
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Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid
(ELSEVIER SCIENCE INC, 2010-06-01)Diabetic mellitus, a chronic metabolic disorder, is one of the most important health problems in the world, especially in developing countries. Our earlier investigations reported the beneficial action of arjunolic acid ... -
Protective Role of Taurine against Arsenic-Induced Mitochondria-Dependent Hepatic Apoptosis via the Inhibition of PKC delta-JNK Pathway
(PUBLIC LIBRARY SCIENCE, 2010-09-07)Background: Oxidative stress-mediated hepatotoxic effect of arsenic (As) is mainly due to the depletion of glutathione (GSH) in liver. Taurine, on the other hand, enhances intracellular production of GSH. Little is known ... -
Effect of Different Strains of Agrobacterium rhizogenes and Nature of Explants on Plumbago indica Hairy Root Culture with Special Emphasis on Root Biomass and Plumbagin Production
(NATURAL PRODUCTS INC, 2010-12)The aim of the present study was to determine the effect of three strains of Agrobacterium rhizogenes (ATCC 15834, A(4) and LBA 9402) and the nature of explants (leaf and stem) on hairy root induction, growth and plumbagin ... -
Efficient acylation and sulfation of carbohydrates using sulfamic acid, a mild, eco-friendly catalyst under organic solvent-free conditions
(ROYAL SOC CHEMISTRY, 2011-05)A fast and efficient acylation of carbohydrate derivatives and free sugars using a stoichiometric quantity of acylating agents in the presence of sulfamic acid, an environmentally benign catalyst, under organic solvent-free ... -
Gain of Cellular Adaptation Due to Prolonged p53 Impairment Leads to Functional Switchover from p53 to p73 during DNA Damage in Acute Myeloid Leukemia Cells
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2010-10-22)Although it has been well established that spermatogenic cells undergo apoptosis when treated with ethanol, the molecular mechanisms behind it remain to be investigated. Adult male mice were given intra-peritoneal injection ... -
Amphotericin B regulates the host immune response in visceral leishmaniasis: reciprocal regulation of protein kinase C isoforms.
(W B SAUNDERS, 2010-07)OBJECTIVES: Treatment of visceral leishmaniasis (VL) is marked by the failure of pentavalent antimonials which has brought amphotericin B (AmpB) to the forefront. In this study we have focused on signaling pathway ... -
Alteration of immune functions and Th1/Th2 cytokine balance in nicotine-induced murine macrophages: Immunomodulatory role of eugenol and N-acetylcysteine
(ELSEVIER SCIENCE, 2011-04)The aim of this study was to evaluate the immune functions by nicotine-induced murine peritoneal macrophages, and Th1/Th2 cytokine balance in it, and concurrently to establish the immunomodulatory role of eugenol, and ... -
Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts
(NATURE PUBLISHING GROUP, 2010-07-01)Immune dysfunction is well documented during tumor progression and likely contributes to tumor immune evasion. CD8(+) cytotoxic T lymphocytes (CTLs) are involved in antigen-specific tumor destruction and CD4(+) T cells are ... -
Synthesis of tri- and pentasaccharide fragments corresponding to the O-antigen of Shigella boydii type 6
(PERGAMON-ELSEVIER SCIENCE, 2010-11-25)A convenient synthetic strategy for the synthesis of the acidic pentasaccharide repeating unit and its trisaccharide fragment corresponding to the O-antigen of Shigella boydii type 6 has been successfully developed A ... -
Mannosylated solid lipid nanoparticles as vectors for site-specific delivery of an anti-cancer drug
(ELSEVIER SCIENCE, 2010-12-20)The purpose of the present study was to investigate the tumor targeting potential of surface tailored solid lipid nanoparticles (SLNs) loaded with an anti-cancer drug doxorubicin HCl (DOX). DOX encapsulating SLNs were ... -
Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: Protective role of arjunolic acid
(ACADEMIC PRESS, 2010-04-15)Present study investigates the beneficial role of arjunolic acid (AA) against the alteration in the cytokine levels and simultaneous activation of oxidative stress responsive signaling pathways in spleen under hyperglycemic ... -
Berberine Chloride Mediates Its Anti-Leishmanial Activity via Differential Regulation of the Mitogen Activated Protein Kinase Pathway in Macrophages
(PUBLIC LIBRARY SCIENCE, 2011-04-05)Background: A complex interplay between Leishmania and macrophages influences parasite survival and necessitates disruption of signaling molecules, eventually resulting in impairment of macrophage function. In this study, ... -
Phytomedicinal Role of Pithecellobium dulce against CCl4-mediated Hepatic Oxidative Impairments and Necrotic Cell Death
(HINDAWI PUBLISHING CORPORATION, 2011)Present study investigates the beneficial role of the aqueous extract of the fruits of Pithecellobium dulce (AEPD) against carbon tetrachloride (CCl4)-induced hepatic injury using a murine model. AEPD has been found to ... -
Nicotine Diminishes Testicular Gametogenesis, Steroidogenesis, and Steroidogenic Acute Regulatory Protein Expression in Adult Albino Rats: Possible Influence on Pituitary Gonadotropins and Alteration of Testicular Antioxidant Status
(OXFORD UNIV PRESS, 2010-08)The present study was done to evaluate the pituitary-testicular activities of rats subjected to chronic nicotine treatment. The testicular key androgenic enzymes activities, plasma and intratesticular testosterone (ITT) ... -
Arabinosylated Lipoarabinomannan-Mediated Protection in Visceral Leishmaniasis through Up-Regulation of Toll-Like Receptor 2 Signaling: An Immunoprophylactic Approach
(OXFORD UNIV PRESS INC, 2010-07-01)Visceral leishmaniasis is characterized by severe immunosuppression of the host cell, resulting in loss of the proinflammatory response. Toll-like receptor 2 (TLR2) is involved in myriad disease forms, including visceral ... -
DNA repair and recombination in higher plants: insights from comparative genomics of arabidopsis and rice
(BIOMED CENTRAL, 2010-07-21)Background: The DNA repair and recombination (DRR) proteins protect organisms against genetic damage, caused by environmental agents and other genotoxic agents, by removal of DNA lesions or helping to abide them.Results: ... -
Ethanol Induces Mouse Spermatogenic Cell Apoptosis In Vivo Through Over-Expression of Fas/Fas-L, p53, and Caspase-3 Along With Cytochrome c Trans location and Glutathione Depletion
(WILEY-LISS, DIV JOHN WILEY & SONS, 2010-09)Although it has been well established that spermatogenic cells undergo apoptosis when treated with ethanol, the molecular mechanisms behind it remain to be investigated. Adult male mice were given intra-peritoneal injection ... -
Is stem twining form of Basella alba L. a naturally occurring variant?
(INDIAN ACAD SCIENCES, 2010-05-25)A naturally occurring circumnutating stem form of Basella alba L. has been characterized in the background of two procumbent stem forms of B. alba L., cultivated commonly as leaf vegetable. The difference between the ... -
Comparative study of the antioxidant and reactive oxygen species scavenging properties in the extracts of the fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis
(BIOMED CENTRAL, 2010-05-13)Background: Cellular damage caused by reactive oxygen species (ROS) has been implicated in several diseases, and hence natural antioxidants have significant importance in human health. The present study was carried out to ... -
A (1→6)-β-glucan from a somatic hybrid of Pleurotus florida and Volvariella volvacea: isolation, characterization, and study of immunoenhancing properties
(ELSEVIER SCI, 2010-05-07)A water-soluble immunoenhancing polysaccharide was isolated from the aqueous extract of fruit bodies of somatic hybrid (Pflo Vv5 FB), obtained through protoplast fusion between Pleurotus florida and Volvariella volvacea ...