Browsing Prof. Pratima Sinha by Title
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The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005-11-11)We show that the budding yeast protein Chl1p, required for sister-chromatid cohesion, also modulates transcriptional silencing at HMR and telomeres. The absence of this protein results in increased silencing at HMR and, ... -
The budding yeast protein Chl1p is required to preserve genome integrity upon DNA damage in S-phase
(OXFORD UNIV PRESS, 2006-11)The budding yeast protein, Chl1p, is required for sister-chromatid cohesion, transcriptional silencing, rDNA recombination and aging. In this work, we show that Chl1p is also required for viability when DNA replication is ... -
The budding yeast protein Sum1 functions independently of its binding partners Hst1 and Sir2 histone deacetylases to regulate microtubule assembly
(WILEY-BLACKWELL, 2010-09)The budding yeast protein Sum1 is a transcription factor that associates with the histone deacetylase Hst1p or, in its absence, with Sir2p to form repressed chromatin. In this study, SUM1 has been identified as an ... -
Constitutive association of Mcm2-3-5 proteins with chromatin in Entamoeba histolytica
(BLACKWELL PUBLISHING LTD, 2005-02)Eukaryotic cells duplicate their genome once and only once per cell cycle. Our earlier studies with the protozoan parasite, Entamoeba histolytica, have shown that genome reduplication may occur several times without nuclear ... -
Immobilization of long-lived radionuclides Eu-152,Eu-154 by selective bioaccumulation in Saccharomyces cerevisiae from a synthetic mixture of Eu-152,Eu-154, Cs-137 and Co-60
(ELSEVIER SCIENCE SA, 2008-06-01)Yeast cells of Saccharomyces cerevisiae were found to accumulate Eu-152.154 radioisotopes selectively from a synthetic mixture of Eu-152.154, Cs-137, and Co-60 radiotracers at neutral pH in both trace and macro level. The ... -
Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence
(ELSEVIER SCIENCE BV, 2005-12-19)Caloric restriction (CR) is the most compelling example of lifespan extension by external manipulation. Although the molecular mechanisms remain unknown, the theory of hormesis has been invoked to explain the life promoting ...