Department of Chemistry: Recent submissions
Now showing items 61-80 of 173
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Expeditious reaction of ninhydrin with active methylene compounds on montmorillonite K10 clay
(SPRINGER WIEN, 2009-02)Ninhydrin reacted expeditiously with thirteen active methylene compounds on montmorillonite K10 clay at room temperature to furnish, in 5 min, a Knoevenagel condensate in one case, aldols in six cases, aldol-derived cyclic ... -
REACTION OF ISATINS WITH ACTIVE METHYLENE COMPOUNDS ON NEUTRAL ALUMINA: FORMATION OF KNOEVENAGEL CONDENSATES AND OTHER INTERESTING PRODUCTS
(PERGAMON-ELSEVIER SCIENCE, 2009-01-01)Isatin and its N-methyl and 5-nitro derivatives underwent smooth reaction with a variety of acyclic and cyclic active methylene compounds on neutral alumina at rt to efficiently furnish Knoevenagel condensates in the ... -
An expedient, regioselective synthesis of novel 2-alkylamino- and 2-alkylthiothiazolo[5,4-e]- and -[4,5-g]indazoles and their anticancer potential
(PERGAMON-ELSEVIER, 2008-07-07)Several novel 2-alkylamino- and 2-alkylthiothiazolo[5,4-e]- and -[4,5-g]indazoles and their 6-alkyl and 8-alkyl derivatives have been synthesised in high overall yields starting from 5-nitro and 6-nitro-indazoles in a ... -
A mild and expedient one-pot synthesis of substituted benzimidazoles in water using a phase-transfer catalyst
(SPRINGER, 2009-04)1-Alkyl/phenyl-2-arylbenzimidazoles have been synthesized in very good to excellent yields by a one-pot condensation of N-alkyl/phenyl-o-phenylenediamines with aryl aldehydes in water at room temperature using cetyl-pyridinium ... -
Helicobacter pylori Protein HP0175 Transactivates Epidermal Growth Factor Receptor through TLR4 in Gastric Epithelial Cells
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY, 2008-11-21)The pathophysiology of Helicobacter pylori-associated gastroduodenal diseases, ulcerogenesis, and carcinogenesis is intimately linked to activation of epidermal growth factor receptor (EGFR) and production of vascular ... -
Pretransitional phenomena in pure states and in a binary mixture of axially and transversàlly dipolar rodlike molecules of near-identical structures
(ISSST, 2009)Mesophase induction generates strong smectic pretransitional fluctuations in the first three phases of a thermotropic polymorphism: Isotropic → Cholesteric → Chiral Smectic-A → Chiral Smectic-C → Chiral Hexatic Smectic → ... -
A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis
(NATURE, 2009-08)Apoptosis is central to the interaction between pathogenic mycobacteria and host macrophages. Caspase-8-dependent apoptosis of infected macrophages, which requires activation of the mitogen-activated protein (MAP) kinase ... -
Novel Role of Phosphorylation-Dependent Interaction between FtsZ and FipA in Mycobacterial Cell Division
(PUBLIC LIBRARY SCIENCE, 2010-01-06)The bacterial divisome is a multiprotein complex. Specific protein-protein interactions specify whether cell division occurs optimally, or whether division is arrested. Little is known about these protein-protein interactions ... -
Novel role of Wag31 in protection of mycobacteria under oxidative stress
(WILEY-BLACKWELL, 2009-07)P>Wag31 of Mycobacterium tuberculosis belongs to the DivIVA family of proteins known to regulate cell morphology in Gram-positive bacteria. Here we demonstrate an unrecognized, novel role of Wag31 in oxidatively stressed ... -
RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis
(WILEY-BLACKWELL, 2010-02)Central to the response of Mycobacterium tuberculosis to environmental stress is the regulation of genes under the control of alternative sigma factors. Sigma E of M. tuberculosis plays an important role in the intracellular ... -
Finding the optimum activation energy in DNA breathing dynamics: a simulated annealing approach
(IOP PUBLISHING, 2009-08-21)We demonstrate how the stochastic global optimization scheme of simulated annealing can be used to evaluate optimum parameters in the problem of DNA breathing dynamics. The breathing dynamics is followed in accordance with ... -
A model for signal transduction during quorum sensing in Vibrio harveyi
(IOP PUBLISHING, 2009-12)We present a framework for analyzing luminescence regulation during quorum sensing in the bioluminescent bacterium Vibrio harveyi. Using a simplified model for signal transduction in the quorum sensing pathway, we identify ... -
Excess adsorption of beta-lactoglobulin on the soft surface of casein powder
(SCIENTIFIC PUBL-INDIA, 2010-02)Extents (Gamma(1)(2)) of adsorption or globular milk protein beta-lactoglobulin (beta lg) from salt solution onto the soft surface of casein powder have been measured as functions or beta lg concentration at pH 6.5 keeping ... -
Computational modeling of differences in the quorum sensing induced luminescence phenotypes of Vibrio harveyi and Vibrio cholerae
(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2011-04-07)Vibrio harveyi and Vibrio cholerae have quorum sensing pathways with similar design and highly homologous components including multiple small RNAs (sRNAs). However, the associated luminescence phenotypes of strains with ... -
An Oligopeptide Transporter of Mycobacterium tuberculosis Regulates Cytokine Release and Apoptosis of Infected Macrophages
(PUBLIC LIBRARY SCIENCE, 2010-08-17)Background: The Mycobacterium tuberculosis genome encodes two peptide transporters encoded by Rv3665c-Rv3662c and Rv1280c-Rv1283c. Both belong to the family of ABC transporters containing two nucleotide-binding subunits, ... -
Microscopic realization of cross-correlated noise processes
(American Institute of Physics, 2010)We present a microscopic theory of cross-correlated noise processes, starting from a Hamiltonian system-reservoir description. In the proposed model, the system is nonlinearly coupled to a reservoir composed of harmonic ... -
Effect of Methylglyoxal Modification of Human alpha-Crystallin on the Structure, Stability and Chaperone Function
(SPRINGER, 2010-11)alpha-Crystallin functions as a molecular chaperone and maintains transparency of eye lens by protecting other lens-proteins. Non-enzymatic glycation of alpha-crystallin by methylglyoxal, plays a crucial role on its chaperone ... -
Generalized Einstein relation in tilted periodic potential: a semiclassical approach
(AMER CHEMICAL SOC, 2010-06-17)This paper concerns the investigation of the quantum motion of a system in a dissipative Ohmic heat bath in the presence of an external field using the traditional system-reservoir model. Using physically motivated initial ... -
AtPoiA, a homogue of mammalian DNA polymerase in Arabidopsis thaliana, is involved in the repair of UV-B induced DNA damage through the dark repair pathway
(OXFORD UNIV PRESS, 2011-02)Plants are constantly exposed to a wide range of environmental genotoxic stress factors including obligatory exposure to UV radiation in sunlight. Here, we report the functional characterization of a DNA repair protein, ... -
Crystal structure and microstructure of cholesteryl oleyl carbonate
(ELSEVIER IRELAND, 2011-01)The crystal structure as well as the microstructure, i.e., size and strain, of crystallites of cholesteryl oleyl carbonate was determined from X-ray powder diffraction data. The X-ray line broadening was analyzed through ...