Department of Chemistry: Recent submissions
Now showing items 41-60 of 173
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Phosphoric acid-on-silica gel: A green catalyst for the synthesis of symmetrical bis(indolyl)alkanes
(PERGAMON-ELSEVIER SCIENCE LTD, 2006-08-01)Orthophosphoric acid, adsorbed on TLC-grade silica gel, has been demonstrated to be an efficient green catalyst for an expeditious and solvent-free one-step synthesis of symmetrical bis(indolyl)alkanes from the reaction ... -
An expeditious approach to Knoevenagel condensation of Meldrum's acid on neutral alumina using microwave irradiation
(BENTHAM SCIENCE PUBL LTD, 2006-11-01)Application of microwave irradiation to Meldrum's acid and aryl aldehydes, both adsorbed on neutral alumina, furnished efficiently the corresponding Knoevenagel condensation products remarkably fast. -
Magnetic field effect on photoinduced electron transfer between dibenzo[a,c]phenazine and different amines in acetonitrile - water mixture
(AMER CHEMICAL SOC,, 2007-02-08)Unlike the simple phenazine (PZ) molecule, one of its derivatives, dibenzo[a,c]phenazine (DBPZ) forms a charge-transfer complex in the triplet state ((ECT)-E-3) with different amines, e.g., N,N-dimethylaniline (DMA), ... -
Isotropic to nematic phase transition in F-actin
(Elsevier B.V, 2007)Like a few other rod-like and semi-rigid polyelectrolytes, filamentous actin (F-actin) shows, respectively, an isotropic to nematic (I-N) phase transition and an aggregation to a hexagonal liquid crystal followed by ... -
Mycobacterium avium -induced matrix metalloproteinase-9 expression occurs in a cyclooxygenase-2-dependent manner and involves phosphorylation- and acetylation-dependent chromatin modification
(Elsevier B.V., 2007-12-01)Matrix metalloproteinases (MMPs) contribute to the matrix-degrading phenotype of mycobacterial diseases. Considering that MMPs could contribute to the mutual exacerbation of both Mycobacterium avium and HIV in coinfections, ... -
Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages
(NATURE PUBLISHING GROUP, 2007-06-02)Expression of early secreted antigenic target protein 6 (ESAT-6) by Mycobacterium tuberculosis is associated with lower innate immune responses to infection. Here we show that ESAT-6 inhibited activation of transcription ... -
Positive feedback and noise activate the stringent response regulator rel in mycobacteria
(PUBLIC LIBRARY SCIENCE, 2008-03-12)Phenotypic heterogeneity in an isogenic, microbial population enables a subset of the population to persist under stress. In mycobacteria, stresses like nutrient and oxygen deprivation activate the stress response pathway ... -
Chaperone-mediated inhibition of tubulin self-assembly
(Elsevier B.V., 2007-04-01)Molecular chaperones are known to play an important role in facilitating the proper folding of many newly synthesized proteins. Here, we have shown that chaperone proteins exhibit another unique property to inhibit tubulin ... -
Methyl glyoxal elevation is associted with oxidative stress in rheumatoid arthritis
(TAYLOR & FRANCIS LTD, 2007)Methyl glyoxal (MG), a metabolic hazard plays a role in pathogenesis of different diseases. We studied the role of MG in cellular oxidative and carbonyl stress in rheumatoid arthritis (RA). 148 RA patients were divided ... -
Zn2+ enhances the molecular chaperone function and stability of α-crystallin
(ELSEVIER, 2008-01-15)α-Crystallin, the major eye lens protein, is a molecular chaperone that plays a crucial role in the suppression of protein aggregation and thus in the long-term maintenance of lens transparency. Zinc is a micronutrient of ... -
Structure, stability, and chaperone function of αA-crystallin: Role of N-terminal region
(JOHN WILEY & SONS, 2007-06-15)Small heat shock protein αA-crystallin, the major protein of the eye lens, is a molecular chaperone. It consists of a highly conserved central domain flanked by the N-terminal and C-terminal regions. In this article we ... -
α-Crystallin assisted refolding of enzyme substrates: Optimization of external parameters
(SPRINGER, 2007-06-01)α-Crystallin is known to act as a molecular chaperone by preventing the aggregation of partially unfolded substrate proteins. It is also known to assist the refolding of a number of denatured enzymes, but the activity yield ... -
Unfolding and refolding of bovine α-crystallin in urea and its chaperone activity
(SPRINGER, 2007-08-01)We undertook an unfolding and refolding study of alpha(L)-crystallin in presence of urea to explore the breakdown and formation of various levels of structure and to find out whether the breakdown of various levels of ... -
Reaction of diethyl mesoxalate with active methylene compounds: An interesting outcome
(SCIENTIFIC PUBL-INDIA, 2008-02-01)Diethyl mesoxalate reacts separately with each of Meldrum's acid, indan-1,3-dione and diethyl malonate - all active methylene compounds - on neutral alumina either at room temperature or under microwave irradiation to ... -
Tosic acid-on-silica gel: A cheap and eco-friendly catalyst for a convenient one-pot synthesis of substituted benzimidazoles
(SPRINGER WIEN, 2007-12-01)2-Substituted and 1,2-disubstited benzimidazoles were prepared efficiently from o-phenylenediamines and aryl aldehydes using p-toluenesulphonic acid (5∈mol%)-on-silica gel as a cheap and environmentally benign catalyst. -
One-pot formation of functionalised 2-piperidinones from arylidenecyanoacetates and methanolic ammonia via tandem reactions
(PERGAMON-ELSEVIER SCIENCE LTD, 2007-12-01)Aryl aldehydes react with ethyl cyanoacetate in methanolic ammonium acetate to expeditiously furnish, besides high yields of arylidenecyanoacetates, 4,6-diaryt-3,5-dicyano-5-ethoxycarbonyl-2-piperidinones in low yields. ... -
A Keggin heteropoly acid as an efficient catalyst for an expeditious, one-pot synthesis of 1-methyl-2-(hetero)arylbenzimidazoles
(PERGAMON-ELSEVIER SCIENCE LTD, 2007-07-23)The Keggin heteropoly acid, silicotungstic acid, H4SiW12O40, has been demonstrated to be highly efficient for an expeditious, one-pot synthesis of 1-methyl-2-(hetero)arylbenzimidazoles from N-methyl-1,2-phenylenediamine ... -
Loss of structural integrity and hydrophobic ligand binding capacity of acetylated and succinylated bovine beta-lactoglobulin
(ELSEVIER, 2009-01)The lysine residues of bovine beta-lactoglobulin (beta-lg) were acetylated and succinylated to investigate the effect of chemical modification on tertiary and secondary structures. Both derivatives showed higher electrophoretic ... -
Water vapour adsorption by L-amino acids at different water activities
(SCIENTIFIC PUBL-INDIA, 2008-12)Experimental studies on the hydration of all 20 L-amino acids by isopiestic vapour pressure method have been carried out in detail. The water vapour adsorption curves of these amino acids resemble type It or type III BET ... -
Unfolding Studies of Escherichia coli Maltodextrin Glucosidase Monitored by Fluorescence Spectroscopy
(SPRINGER, 2008-12)Equilibrium unfolding of a 69-kDa monomeric Escherichia coli maltodextrin, glucosidase (MalZ) was studied using intrinsic and extrinsic fluorescence spectroscopy. The unfolding transition of MaIZ followed a three-state ...