Browsing Department of Molecular Medicine -- (Formerly Animal Physiology before 2007) by Issue Date
Now showing items 1-20 of 219
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Stimulation of AChE activity in relation to changes in electron microscopic structure of adult rat cerebrocortical synaptosomes pretreated with 3-5-3 '-triiodo-L-thyronine
(LIPPINCOTT WILLIAMS & WILKINS, 2003-08-06)Triiodothyronine (T-3) stimulated AChE activity in depolarization-induced intact synaptosomes (isolated from adult rat cerebral cortex) suspended in calcium-supplemented choline chloride buffer in a time-dependent manner ... -
The Bcl-2 transgene protects T cells from renal cell carcinoma-mediated apoptosis
(AMER ASSOC CANCER RESEARCH, 2003-08-15)Purpose: Tumors induce T-cell apoptosis as a mechanism. of inhibiting antitumor immunity. Using coculture experiments, it has been shown that tumor lines stimulate T-cell apoptosis by a pathway involving a mitochondrial ... -
Putative L-triiodothyronine receptors in the liver nuclei of mature tropical toad, Bufo melanostictus
(VERLAG Z NATURFORSCH, 2004-01)Thyroid hormones exert a major role in growth and differentiation of almost all types of tissues in animals, particularly in amphibian metamorphosis, through its specific nuclear receptor activation followed by gene ... -
Alterations in air-sac and skeleton of triploid Heteropneustes fossilis
(BLACKWELL PUBLISHING LTD, 2004-01)Triploid stinging catfish Heteropneustes fossilis, when produced by cold shock, showed abnormalities in their air-sacs and skeletons. -
Cardiac Overexpression of Myotrophin Triggers Myocardial Hypertrophy and Heart Failure in Transgenic Mice
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2004-05-07)Cardiac hypertrophy and heart failure remain leading causes of death in the United States. Many studies have suggested that, under stress, myocardium releases factors triggering protein synthesis and stimulating myocyte ... -
Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio
(ELSEVIER SCI IRELAND LTD, 2004-06-25)It is known that cancer is associated with altered immune function. We demonstrated earlier that black tea inhibits tumor growth in a dose-dependent manner. Here, we report that apoptosis was the cause of immunocyte death ... -
Regulation of myotrophin gene by pressure overload and stretch
(KLUWER ACADEMIC PUBL, 2004-07-01)Hemodynamic load is a major determinant of cardiac mass and its phenotype, but very little is known about how mechanical load is converted into intracellular signals of gene expression and regulation. We have shown earlier ... -
Tumor-induced dysfunction in T lymphocytes: increased sensitivity to apoptosis
(SPRINGER, 2004-09) -
Effect of renal cell carcinomas on the development of type 1 T-cell responses( Conference Paper )
(AMER ASSOC CANCER RESEARCH, 2004-09-15)Purpose: We reported that in renal cell carcinoma patients with active disease, T-cell reactions to the tumor-associated antigens MAGE-6 and EphA2 are highly skewed toward T(H)2-type cytokine responses [interleukin (IL) ... -
P27 expression is regulated by separate signaling pathways, downstream of Ras, in each cell cycle phase
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-11-01)The cyclin inhibitory protein p27Kip1 (p27) plays a vital role in regulating cell proliferation in response to the extracellular growth environment. Active proliferation requires the suppression of p27 levels throughout ... -
The biology of triploid fish
(SPRINGER, 2004-12)This review deals with major areas of triploidy research in fish. It includes not only methods for induction and detection of triploidy but also the impact of triploidy on morphology, anatomy, growth, haematology, energetics, ... -
Black tea protects thymocytes in tumor-bearing animals by differential regulation of intracellular ROS in tumor cells and thymocytes
(BEGELL HOUSE INC, 2005)The accumulated in vitro evidence indicates that many tumors induce T-cell apoptosis as a mechanism of inhibiting antitumor activity. This downregulation of cell-mediated immune functions occurring at the late stages of ... -
Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin
(ELSEVIER SCI LTD, 2005)Background: The true therapeutic benefit of the use of natural products, especially acceptable dietary components such as curcumin, which can spare the normal cells and boost host immunity, has opened new horizons in cancer ... -
Over-expressed IgG2 antibodies against O-acetylated sialoglycoconjugates incapable of proper effector functioning in childhood acute lymphoblastic leukemia
(OXFORD UNIV PRESS, 2005-02)Earlier studies have demonstrated an over-expression of 9-O-acetylated sialoglycoconjugates (9-OAcSGs) on lymphoblasts, concomitant with high titers of anti-9-OAcSGs in childhood acute lymphoblastic leukemia (ALL). The ... -
The regulation of S phase initiation by p27Kip1 in NIH3T3 cells
(LANDES BIOSCIENCE, 2005-04)Most eukaryotic cells become committed to divide once DNA synthesis begins. This critical event is controlled in yeast and Xenopus oocytes by the degradation of cyclin inhibitory proteins, while in mammalian cells ... -
Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G(2) phase of cell cycle in a p53-dependent manner
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2005-05-20)Curcumin (diferuloylmethane) is known to induce apoptosis in tumor cells. In asynchronous cultures, with time-lapse video-micrography in combination with quantitative fluorescence microscopy, we have demonstrated that ... -
Characterization and functional significance of myotrophin: A gene with multiple transcripts
(ELSEVIER IRELAND LTD, 2005-06-20)The underlying mechanism for the development of cardiac hypertrophy that advances to heart failure is not known. Many factors have been implied to play a role in this process. Among others, we have isolated and identified ... -
Preventive and curative role of a 43 kD protein from the leaves of the herb Cajanus indicus L on thioacetamide-induced hepatotoxicity in vivo
(ELSEVIER IRELAND LTD, 2005-09-01)An approximately 43 kD protein has been isolated and purified from the herb Cajanus indicits L and believed to be the most active principle for its hepatoprotective action. In this study, experiments have been performed ... -
Curative role of the aqueous extract of the herb, Phyllanthus niruri, against nimesulide induced oxidative stress in murine liver
(Elsevier B.V., 2005-10-01)The present study was conducted to evaluate whether the aqueous extract of the herb, Phyllanthus niruri (PN) can effectively cure liver from nimesulide (NIM) induced oxidative stress in vivo. In our experiments, we have ... -
Failure in peripheral immuno-surveillance due to thymic atrophy: Importance of thymocyte maturation and apoptosis in adult tumor-bearer(M-T-2005)
(PERGAMON-ELSEVIER SCIENCE LTD, 2005-10-07)Tumor-induced immunosuppression often leads to failure in cancer therapy. Here, in an attempt to understand the course of tumor-dependent immunosuppression in young adult murine model, we found that in Ehrlich's ascites ...