Now showing items 61-80 of 83
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Conserved residue clusters at protein-protein interfaces and their use in binding site identification
(BIOMED CENTRAL, 2010-05-27)Background: Biological evolution conserves protein residues that are important for structure and function. Both protein stability and function often require a certain degree of structural co-operativity between spatially ... -
The Subunit Interfaces of Weakly Associated Homodimeric Proteins
(ACADEMIC PRESS, 2010-04-23)We analyzed subunit interfaces in 315 homodimers with an X-ray structure in the Protein Data Bank, validated by checking the literature for data that indicate that the proteins are dimeric in solution and that, in the case ... -
On nucleotide solvent accessibility in RNA structure
(ELSEVIER SCIENCE, 2010-09-01)Sequence dependence of solvent accessibility in globular and membrane proteins is well established. However, this important structural property has been poorly investigated in nucleic acids. On the other hand investigation ... -
Insights into the genomic features and evolutionary impact of the genes configuring duplicated pseudogenes in human
(ELSEVIER SCIENCE, 2010-09-24)Pseudogenes, regarded as 'genomic fossils', are DNA sequences resembling functional genes in perspective of sequence homology but completely non-functional. In this study, we explored the unique characteristic features of ... -
Protein Connectivity and Protein Complexity Promotes Human Gene Duplicability in a Mutually Exclusive Manner
(OXFORD UNIV PRESS, 2010-10)It has previously been reported that protein complexity (i.e. number of subunits in a protein complex) is negatively correlated to gene duplicability in yeast as well as in humans. However, unlike in yeast, protein ... -
New Direction to the Solution of Protein Folding Problem
(ADENINE, 2011-02)No abstract available. -
Faculty Publication List : Dept. of Bioinformatics , 2003-04
(Bose Institute, 2004) -
Faculty Publication List : Dept. of Bioinformatics , 2002-03
(Bose Institute, 2003) -
Faculty Publication List : Dept. of Bioinformatics , 2001-02
(Bose Institute, 2002) -
Faculty Publication List : Dept. of Bioinformatics , 2000-01
(Bose Institute, 2001) -
Faculty Publication List : Dept. of Bioinformatics, 2004-05
(Bose Institute, 2005) -
Faculty Publication List : Dept. of Bioinformatics, 2005-06
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Faculty Publication List : Dept. of Bioinformatics, 2007-08
(Bose Institute, 2008) -
Faculty Publication List : Dept. of Bioinformatics, 2006-07
(Bose Institute, 2007) -
Faculty Publication List : Dept. of Bioinformatics, 2008-09
(Bose Institute, 2009) -
Faculty Publication List : Dept. of Bioinformatics, 2009-10
(Bose Institute, 2010) -
Faculty Publication List : Dept. of Bioinformatics, 2010-11
(Bose Institute, 2011) -
Protein complex forming ability is favored over the features of interacting partners in determining the evolutionary rates of proteins in the yeast protein-protein interaction networks
(BioMed Central Ltd, 2010-11-12)Background: Evolutionary rates of proteins in a protein-protein interaction network are primarily governed by the protein connectivity and/or expression level. A recent study revealed the importance of the features of ... -
Understanding the Effect of Secondary Structures and Aggregation on Human Protein Folding Class Evolution
(Springer, 2010-07-01)Using several model organisms it has been shown earlier that protein designability is related to contact density or fraction of buried residues and influence protein evolutionary rates dramatically. Here, using Homo ... -
Exploring the differences in evolutionary rates between monogenic and polygenic disease genes in human.
(Oxford University Press, 2010-04)Comparative analyses on disease and nondisease (ND) genes have greatly facilitated the understanding of human diseases. However, most studies have grouped all the disease genes together and have performed comparative ...