Browsing Department of Biophysics by Title

Analysis Of Biological Networks And Insight Into The Structures Of Biomolecules Associated With Neurodegenerative Diseases

Chatterjee, Paulami, Auth; Roy, Debjani, Supervisor (2017)

A Bio-active compound from the tissue extract of sea cucumber holothuria scabra

Ganguly, Anutosh, Auth; Roy, Siddhartha, Supervisor (2005)

Biphasic kinetics of the colchicine-tubulin interaction: Role of amino acids surrounding the a ring of bound colchicine molecule

Gupta, S.; Banerjee, M.; Poddar, A.; Banerjee, A.; Basu, Gautam; Roy, Debjani; Bhattacharyya, Bhabatarak (AMER CHEMICAL SOC, 2005-08-02)

Isotypes of vertebrate tubulin have variable amino acid sequences, which are clustered at their C-terminal ends. Isotypes bind colchicine at different on-rates and affinity constants. The kinetics of colchicine binding to ...

Characterisation of a few organic compounds of biological interest by x-ray crystallography computer modelling studies of a protease syster and its complexes

Dey, Indrani, Auth; Banerjee, Asok, Supervisor (1994)

Characterisation of biopolymers and molecules of biological importance by x-ray crystallographic methods and modelling.

Bera, Asim Kumar, Auth; Banerjee, Asok, Supervisor (2000)

A chimaeric glutamyl:glutaminyl-tRNA synthetase: implications for evolution

Saha, Rajesh; Dasgupta, Saumya; Basu, Gautam; Roy, Siddhartha (PORTLAND, 2009-01-15)

aaRSs (aminoacyl-tRNA synthetases) are multi-domain proteins that have evolved by domain acquisition. The anti-codon binding domain was added to the more ancient catalytic domain during aaRS evolution. Unlike in eukaryotes, ...

Cloning, expression, purification, and characterization of Vibrio cholerae transcriptional activator, HlyU

Saha, R. P.; Basu, Gautam; Chakrabarti, Pinak (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2006-07)

The HlyU from Vibrio cholerae, involved in the transcriptional regulation of haemolysin genes, plays an important role in the regulation of virulence gene expression. We have cloned, over-expressed and purified HlyU from ...

Codon usage and gene expression pattern of Stenotrophomonas maltophilia R551-3 for pathogenic mode of living

Banerjee, Rachana; Roy, Debjani (ACADEMIC PRESS, 2009-12-11)

Stenotrophomonas maltophilia strain R551-3 is a multiple-antibiotic-resistant opportunistic human pathogen involved in nosocomial infections. It has a widely distributed GC-rich (>66%) genome. Analysis of differential ...

Comparative structural studies of psychrophilic and mesophilic protein homologues by molecular dynamics simulation

Kundu, Sangeeta; Roy, Debjani (ELSEVIER, 2009-06)

Comparative molecular dynamics simulations of psychrophilic type III antifreeze protein from the North-Atlantic ocean-pout Macrozoarces americanus and its corresponding mesophilic counterpart, the antifreeze-like domain ...

Computational study of glyceraldehyde-3-phosphate dehydrogenase of Entamoeba histolytica: Implications for structure-based drug design

Kundu, Sangeeta; Roy, Debjani (ADENINE, 2007-08)

Glyceraldehyde-3 -phosphate dehydrogenase (GAPDH) of the pathogenic protozoa Entamoeba histolytica (Eh) is a major glycolytic enzyme and an attractive drug target since this parasite lacks a functional citric acid cycle ...

Conformational preferences of a short Aib/Ala-based water-soluble peptide as a function of temperature

Banerjee, Raja; Chattopadhyay, Sarbani; Basu, Gautam (WILEY-BLACKWELL, 2009-07)

The amino acid Aib predisposes a peptide to be helical with context-dependent preference for either 3(10)- or alpha- or a mixed helical conformation. Short peptides also show an inherent tendency to be unfolded. To ...

Coulomb energies of protein-protein complexes with monopole-free charge distributions

Das, Madhurima; Basu, Gautam (ELSEVIER SCIENCE, 2009-04)

From an analysis of Coulomb energy distributions of a large set of protein-protein complexes we show that the positive tail in the energy distribution disappears when the monopole-monopole term, the only energy term ...

Critical structural study of protease inhibitors and some molecules of biological importance

Chakraborty, Sibani, Auth; Baberjee, Asok, Supervisor (2002)

Crystal and molecular structure of specific pyrimidine compounds and analogs of biological importance by biophysical methods.

Biswas, Goutam, Auth; Banerjee, Asok, Supervisor (1989)

Differential colchicine-binding across eukaryotic families: The role of highly conserved Pro268 beta and Ala248 beta residues in animal tubulin

Banerjee, Mithu; Roy, Debjani; Bhattacharyya, B; Basu, Gautam (ELSEVIER, 2007-10-30)

Colchicine-tubulin interaction, responsible for the disruption of microtubule formation, has immense pharmacological importance but is poorly understood in terms of its biological significance. The interaction is characterized ...

Electrostatic potential of nucleotide-free protein is sufficient for discrimination between adenine and guanine-specific binding sites

Basu, Gautam; Sivanesan, D.; Kawabata, T.; Go, N. (ACADEMIC PRESS, 2004-09-17)

Despite sharing many common features, adenine-binding and guanine-binding sites in proteins often show a clear preference for the cognate over the non-cognate ligand. We have analyzed electrostatic potential (ESP) patterns ...

Expanded turn conformations: Characterization and sequence-structure correspondence in alpha-turns with implications in helix folding

Dasgupta, B.; Pal, L.; Basu, Gautam; Chakrabarti, Pinak (WILEY-BLACKWELL,, 2004-05-01)

Like the beta-turns, which are characterized by a limiting distance between residues two positions apart (i, i+3), a distance criterion (involving residues at positions i and i+4) is used here to identify a-turns from a ...