DSpace at Bose Institute: Recent submissions
Now showing items 1281-1300 of 2749
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Positive feedback and noise activate the stringent response regulator rel in mycobacteria
(PUBLIC LIBRARY SCIENCE, 2008-03-12)Phenotypic heterogeneity in an isogenic, microbial population enables a subset of the population to persist under stress. In mycobacteria, stresses like nutrient and oxygen deprivation activate the stress response pathway ... -
Homology modeling and molecular dynamics study of the interactions of SoxY and SoxZ: The central player of biochemical oxidation of sulfur anions in Pseudaminobacter salicylatoxidans
(Academic Journals, 2007)Microbial redox reactions of inorganic sulfur compounds, mainly the sulfur anions, are one of the vital reactions responsible for the environmental sulfur balance. These reactions are mediated by phylogenetically diverse ... -
Interaction geometry involving planar groups in protein-protein interfaces
(WILEY-BLACKWELL, 2007-04)The geometry of interactions of planar residues is nonrandom in protein tertiary structures and gives rise to conventional, as well as nonconventional. (X-H center dot center dot center dot pi, X-H center dot center dot ... -
Chaperone-mediated inhibition of tubulin self-assembly
(Elsevier B.V., 2007-04-01)Molecular chaperones are known to play an important role in facilitating the proper folding of many newly synthesized proteins. Here, we have shown that chaperone proteins exhibit another unique property to inhibit tubulin ... -
Peptide segments in protein-protein interfaces
(INDIAN ACADEMY SCIENCES, 2007-01)An important component of functional genomics involves the understanding of protein association. The interfaces resulting from protein-protein interactions - (i) specific, as represented by the homodimeric quaternary ... -
Methyl glyoxal elevation is associted with oxidative stress in rheumatoid arthritis
(TAYLOR & FRANCIS LTD, 2007)Methyl glyoxal (MG), a metabolic hazard plays a role in pathogenesis of different diseases. We studied the role of MG in cellular oxidative and carbonyl stress in rheumatoid arthritis (RA). 148 RA patients were divided ... -
On the origin of synonymous codon usage divergence between thermophilic and mesophilic prokaryotes
(ELSEVIER, 2007-12-22)Synonymous codon usage analysis between thermophilic and mesophilic prokaryotes has gained wide attention in recent years. Although it is known that thermophilic and mesophilic prokaryotes use different subset of synonymous ... -
Macromolecular recognition in the Protein Data Bank
(WILEY-BLACKWELL, 2007-01)Crystal structures deposited in the Protein Data Bank illustrate the diversity of biological macromolecular recognition: transient interactions in protein-protein and protein DNA complexes and permanent assemblies in ... -
Geometry of nonbonded interactions involving planar groups in proteins
(PERGAMON-ELSEVIER SCIENCE LTD, 2007-09)Although hydrophobic interaction is the main contributing factor to the stability of the protein fold, the specificity of the folding process depends on many directional interactions. An analysis has been carried out on ... -
Different functional classes of genes are characterized by different compositional properties
(ELSEVIER, 2007-12-22)A compositional analysis on a set of human genes classified in several functional classes was performed. We found out that the GC3, i.e. the GC level at the third codon positions, of the genes involved in cellular metabolism ... -
Zn2+ enhances the molecular chaperone function and stability of α-crystallin
(ELSEVIER, 2008-01-15)α-Crystallin, the major eye lens protein, is a molecular chaperone that plays a crucial role in the suppression of protein aggregation and thus in the long-term maintenance of lens transparency. Zinc is a micronutrient of ... -
Structure, stability, and chaperone function of αA-crystallin: Role of N-terminal region
(JOHN WILEY & SONS, 2007-06-15)Small heat shock protein αA-crystallin, the major protein of the eye lens, is a molecular chaperone. It consists of a highly conserved central domain flanked by the N-terminal and C-terminal regions. In this article we ... -
α-Crystallin assisted refolding of enzyme substrates: Optimization of external parameters
(SPRINGER, 2007-06-01)α-Crystallin is known to act as a molecular chaperone by preventing the aggregation of partially unfolded substrate proteins. It is also known to assist the refolding of a number of denatured enzymes, but the activity yield ... -
Secondary structure based analysis and classification of biological interfaces: identification of binding motifs in protein-protein interactions
(OXFORD UNIV PRESS, 2007-08-01)Motivation: The increasing amount of data on protein-protein interaction needs to be rationalized for deriving guidelines for the alteration or design of an interface between two proteins. Results: We present a detailed ... -
Structural considerations for designing adenosine analogs as selective inhibitors of Trichomonas sp. glyceraldehyde-3- phosphate dehydrogenase.
(IOS Press, 2007)Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of pathogenic protozoa Trichomonas vaginalis (TvGAPDH) is an attractive drug target since this parasite lacks functional citric acid cycle and is dependent solely on glycolysis ... -
Differential colchicine-binding across eukaryotic families: The role of highly conserved Pro268 beta and Ala248 beta residues in animal tubulin
(ELSEVIER, 2007-10-30)Colchicine-tubulin interaction, responsible for the disruption of microtubule formation, has immense pharmacological importance but is poorly understood in terms of its biological significance. The interaction is characterized ... -
Immobilization of long-lived radionuclides Eu-152,Eu-154 by selective bioaccumulation in Saccharomyces cerevisiae from a synthetic mixture of Eu-152,Eu-154, Cs-137 and Co-60
(ELSEVIER SCIENCE SA, 2008-06-01)Yeast cells of Saccharomyces cerevisiae were found to accumulate Eu-152.154 radioisotopes selectively from a synthetic mixture of Eu-152.154, Cs-137, and Co-60 radiotracers at neutral pH in both trace and macro level. The ... -
Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin
(JOHN WILEY & SONS, 2008-01)In this review, an attempt has been made to throw light on the mechanism of action of colchicine and its different analogs as anti-cancer agents. Colchicine interacts with tubulin and perturbs the assembly dynamics of ... -
Computational study of glyceraldehyde-3-phosphate dehydrogenase of Entamoeba histolytica: Implications for structure-based drug design
(ADENINE, 2007-08)Glyceraldehyde-3 -phosphate dehydrogenase (GAPDH) of the pathogenic protozoa Entamoeba histolytica (Eh) is a major glycolytic enzyme and an attractive drug target since this parasite lacks a functional citric acid cycle ... -
Deuterium oxide stabilizes conformation of tubulin: A biophysical and biochemical study
(KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY, 2008-01-31)The present study was aimed to elucidate the mechanism of stabilization of tubulin by deuterium oxide (D2O). Rate of decrease of tryptophan fluorescence during aging of tubulin at 4 degrees C and 37 degrees C was significantly ...