Browsing Parames Chandra. Sil by Issue Date
Now showing items 1-20 of 62
-
Cardiac Overexpression of Myotrophin Triggers Myocardial Hypertrophy and Heart Failure in Transgenic Mice
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2004-05-07)Cardiac hypertrophy and heart failure remain leading causes of death in the United States. Many studies have suggested that, under stress, myocardium releases factors triggering protein synthesis and stimulating myocyte ... -
Regulation of myotrophin gene by pressure overload and stretch
(KLUWER ACADEMIC PUBL, 2004-07-01)Hemodynamic load is a major determinant of cardiac mass and its phenotype, but very little is known about how mechanical load is converted into intracellular signals of gene expression and regulation. We have shown earlier ... -
Characterization and functional significance of myotrophin: A gene with multiple transcripts
(ELSEVIER IRELAND LTD, 2005-06-20)The underlying mechanism for the development of cardiac hypertrophy that advances to heart failure is not known. Many factors have been implied to play a role in this process. Among others, we have isolated and identified ... -
Preventive and curative role of a 43 kD protein from the leaves of the herb Cajanus indicus L on thioacetamide-induced hepatotoxicity in vivo
(ELSEVIER IRELAND LTD, 2005-09-01)An approximately 43 kD protein has been isolated and purified from the herb Cajanus indicits L and believed to be the most active principle for its hepatoprotective action. In this study, experiments have been performed ... -
Curative role of the aqueous extract of the herb, Phyllanthus niruri, against nimesulide induced oxidative stress in murine liver
(Elsevier B.V., 2005-10-01)The present study was conducted to evaluate whether the aqueous extract of the herb, Phyllanthus niruri (PN) can effectively cure liver from nimesulide (NIM) induced oxidative stress in vivo. In our experiments, we have ... -
Protein isolate from the herb, Phyllanthus niruri, protects liver from acetaminophen induced toxicity
(ELSEVIER, 2006-01-01)Phyllanthus niruri L. (Euphorbiaceae) is a well-known hepatoprotective herbal plant. The aim of this study was to investigate the hepatoprotective action of the protein isolate of Phyllanthus niruri (P. niruri) against ... -
Protective effect of a 43 kD protein from the leaves of the herb, cajanus indicus L on chloroform induced hepatic-disorder
(SPRINGER SINGAPORE PTE LTD, 2006-03-31)Cajanus indicus is a herb with medicinal properties and is traditionally used to treat various forms of liver disorders. Present study aimed to evaluate the effect of a 43 kD protein isolated from the leaves of this herb ... -
Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress.
(ELSEVIER, 2006-05-01)Present study was conducted to evaluate the role of a protein fraction (PI, protein isolate) of the herb, Phyllanthus niruri (P. niruri) against nimesulide-induced oxidative stress in vivo using a murine model. Mice were ... -
The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties
(JOHN WILEY & SONS LTD, 2006-07-01)The aim of this study was to investigate the hepatoprotective action of the protein fraction of Phyllanthus niruri against acetaminophen (APAP) hepatotoxicity. The partially purified protein fraction of P. niruri was ... -
A 43 kDa protein from the herb Cajanus indicus L. protects thioacetamide induced cytotoxicity in hepatocytes
(PERGAMON-ELSEVIER SCIENCE LTD, 2006-08-01)The aim of this study was to investigate the role of a hepatoprotective protein isolated from the herb Cajanus indicus L. on thioacetamide (TAA) induced toxicity in isolated mouse hepatocytes. In vitro cell viability, ... -
Purification and characterization of a 43 kD hepatoprotective protein from the herb Cajanus indicus L.
(SPRINGER, 2006-09-01)Cajanus indicus L, a herb, is popularly known for its hepatoprotective activity. Aqueous extract of the leaves of this plant contains hepatoprotective and hepatostimulatory molecule(s). Present study was aimed to isolate, ... -
Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders
(ELSEVIER, 2006-09-01)Background: Carbon tetrachloride (CCI4) is a well-known hepatotoxin and exposure to this chemical is known to induce oxidative stress and causes liver injury by the formation of free radicals. Acute and chronic renal damage ... -
Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo
(ELSEVIER, 2006-10-01)Nimesulide (NIM), an atypical non-steroidal anti-inflammatory drug (NSAID) is also used as analgesic. In the present study, we evaluated its effect on the prooxidant-antioxidant system of liver and the hepatoprotective ... -
A 43-kDa protein from the leaves of the herb Cajanus indicus L. modulates chloroform induced hepatotoxicity in vitro
(Informa Healthcare., 2006-12-01)A 43-kDa protein isolated from the leaves of the herb Cajanus indicus L. has been shown to possess a protective role against drug- and toxin- induced hepatotoxicity both in vivo and in vitro . The current study was conducted ... -
Protective role of Phyllanthus niruri against nimesulide induced hepatic damage
(ELSEVIER, 2007)Present study aimed to evaluate the protective role of the aqueous extract of Phyllanthus niruri (P. niruri) against nimesulide-induced hepatic disorder in mice by determining levels of glutamate oxaloacetate transaminase ... -
Aqueous extract of the bark of Terminalia arjuna plays a protective role against sodium-fluoride-induced hepatic and renal oxidative stress
(SPRINGER TOKYO, 2007)Fluoride is an environmental and industrial pollutant. It has already been reported that the accumulation of fluoride can alter the activities of some enzymes involved in the free-radical metabolism and also decrease the ... -
Galactosamine-induced hepatotoxic effect and hepatoprotective role of a protein isolated from the herb Cajanus indicus L in vivo
(JOHN WILEY & SONS INC, 2007)D(+)-Galactosamine is a well-known experimental hepatotoxin. The present study was conducted to determine the protective role of a 43-kD protein isolated from the leaves of the herb Cajanus indices L against D(+)-galactosamine ... -
Protein isolate from the herb Phyllanthus niruri modulates carbon tetrachloride-induced cytotoxicity in hepatocytes
(TAYLOR & FRANCIS INC, 2007-01-01)Phyllanthus niruri is a well-known hepatoprotective herbal plant. In the present study, hepatoprotective potential of the protein isolate of P. niruri was investigated against carbon tetrachloride (CCl4)-induced hepatoxicity ... -
Amelioration of galactosamine-induced nephrotoxicity by a protein isolated from the leaves of the herb, Cajanus indicus L.
(ELSEVIER, 2007-04-25)BACKGROUND: Galactosamine (GalN), an established experimental toxin, mainly causes liver injury via the generation of free radicals and depletion of UTP nucleotides. Renal failure is often associated with end stage liver ... -
A 43 kD protein isolated from the herb Cajanus indicus L attenuates sodium fluoride-induced hepatic and renal disorders in vivo
(SPRINGER, 2007-05-31)The herb, Cajanus indicus L, is well known for its hepatoprotective action. A 43 kD protein has been isolated, purified and partially sequenced from the leaves of this herb. A number of in vivo and in vitro studies carried ...