Browsing Parames Chandra. Sil by Title
Now showing items 1-20 of 62
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A 43 kD protein from the herb, Cajanus indicus L., protects against fluoride induced oxidative stress in mice erythrocytes
(ELSEVIER, 2007-05-31)Present study has been carried out to evaluate the protective and curative roles of a 43 kD protein isolated from the herb Cajanus indicus L. on sodium fluoride (NaF) induced toxicity in mice erythrocytes. In the preventive ... -
A 43 kD protein isolated from the herb Cajanus indicus L attenuates sodium fluoride-induced hepatic and renal disorders in vivo
(SPRINGER, 2007-05-31)The herb, Cajanus indicus L, is well known for its hepatoprotective action. A 43 kD protein has been isolated, purified and partially sequenced from the leaves of this herb. A number of in vivo and in vitro studies carried ... -
A 43 kDa protein from the herb Cajanus indicus L. protects thioacetamide induced cytotoxicity in hepatocytes
(PERGAMON-ELSEVIER SCIENCE LTD, 2006-08-01)The aim of this study was to investigate the role of a hepatoprotective protein isolated from the herb Cajanus indicus L. on thioacetamide (TAA) induced toxicity in isolated mouse hepatocytes. In vitro cell viability, ... -
A 43-kDa protein from the leaves of the herb Cajanus indicus L. modulates chloroform induced hepatotoxicity in vitro
(Informa Healthcare., 2006-12-01)A 43-kDa protein isolated from the leaves of the herb Cajanus indicus L. has been shown to possess a protective role against drug- and toxin- induced hepatotoxicity both in vivo and in vitro . The current study was conducted ... -
Acetaminophen induced acute liver failure via oxidative stress and JNK activation: Protective role of taurine by the suppression of cytochrome P450 2E1
(TAYLOR & FRANCIS, 2010-03)The present study was carried out to investigate whether taurine plays any beneficial role in acetaminophen (APAP)-induced acute hepatotoxicity. APAP exposure increased the plasma levels of ALT, ALP, LDH, TNF-alpha and NO ... -
Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: Therapeutic potential of arjunolic acid
(ELSEVIER IRELAND, 2010-01-31)Acetaminophen (APAP) causes acute and chronic renal failure. The mechanisms leading to hepatic injury have been extensively studied, but the molecular mechanisms regarding APAP-induced nephro-toxicity are poorly defined. ... -
Amelioration of cadmium-induced cardiac impairment by taurine
(ELSEVIER IRELAND, 2008-07-30)The present study has been designed to investigate the protective role of taurine (2-aminoethanesulfonic acid), a sulfur containing conditionally essential amino acid, against cadmium-induced cardiac dysfunction in mice. ... -
Amelioration of galactosamine-induced nephrotoxicity by a protein isolated from the leaves of the herb, Cajanus indicus L.
(ELSEVIER, 2007-04-25)BACKGROUND: Galactosamine (GalN), an established experimental toxin, mainly causes liver injury via the generation of free radicals and depletion of UTP nucleotides. Renal failure is often associated with end stage liver ... -
Anti-oxidative effect of a protein from Cajanus indicus L against acetaminophen-induced hepato-nephro toxicity
(SPRINGER SINGAPORE, 2007-11-30)Overdoses of acetaminophen cause hepato-renal oxidative stress. The present study was undertaken to investigate the protective effect of a 43 kDa protein isolated from the herb Cajanus indicus, against acetaminophen-induced ... -
Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders
(ELSEVIER, 2006-09-01)Background: Carbon tetrachloride (CCI4) is a well-known hepatotoxin and exposure to this chemical is known to induce oxidative stress and causes liver injury by the formation of free radicals. Acute and chronic renal damage ... -
Aqueous extract of the bark of Terminalia arjuna plays a protective role against sodium-fluoride-induced hepatic and renal oxidative stress
(SPRINGER TOKYO, 2007)Fluoride is an environmental and industrial pollutant. It has already been reported that the accumulation of fluoride can alter the activities of some enzymes involved in the free-radical metabolism and also decrease the ... -
Arjunolic acid attenuates arsenic-induced nephrotoxicity
(ELSEVIER, 2008-10)Arsenic is highly toxic naturally occurring element that affects numerous organ systems in humans. Present study was designed to investigate the preventive role of a triterpenoid saponin, arjunolic acid (AA) against ... -
Arjunolic acid, a triterpenoid saponin, ameliorates arsenic-induced cyto-toxicity in hepatocytes
(ELSEVIER, 2007-12-15)Arsenic is a well-established environmental toxin, which damages various organs of the body. A triterpenoid saponin, arjunolic acid (AA) has been isolated from the bark of Terminalia arjuna. The present study was conducted ... -
Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection
(ELSEVIER SCIENCE, 2010-02-15)Acetaminophen (APAP) is a widely used analgesic and antipyretic drug and is safe at therapeutic closes but its overdose frequently causes liver injury. In earlier studies, we demonstrated that arjunolic acid (AA) has a ... -
Arsenic-induced oxidative cerebral disorders: Protection by taurine
(TAYLOR & FRANCIS, 2009-04)The present study was conducted to investigate whether the conditionally essential amino acid, taurine, could play any protective role against the potent neurotoxin arsenic (As)-induced oxidative impairment in the rat ... -
Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid
(SPRINGER, 2008-03)Arsenic, one of the most harmful metalloids, is ubiquitous in the environment. The present study has been carried out to investigate the protective role of a triterpenoid saponin, arjunolic acid (AA) against arsenic-induced ... -
Attenuation of acetaminophen-induced hepatotoxicity in vivo and in vitro by a 43-kD protein isolated from the herb Cajanus indicus L
(TAYLOR & FRANCIS INC, 2007-08)The aim of this study was to evaluate the hepatoprotective role of a 43-kD protein (Hp-P) isolated from the leaves of Cajanus indicus L. against acetaminophen (APAP)-induced toxicity in mouse liver and in isolated hepatocytes. ... -
Attenuation of cadmium chloride induced cytotoxicity in murine hepatocytes by a protein isolated from the leaves of the herb Cajanus indicus L.
(SPRINGER, 2007-06)Cadmium has been recognized as a strong environmental pollutant. Exposure to this heavy metal occurs through the intake of foodstuffs, drinking water and also via the inhalation of air. Present study was conducted to ... -
Cadmium-induced neurological disorders: prophylactic role of taurine
(JOHN WILEY & SONS, 2008-11)The present study was conducted to investigate whether the conditionally essential amino acid taurine could play any protective role against the potent neurotoxin cadmium (Cd)-induced oxidative impairment in mice brain. ... -
Cardiac Overexpression of Myotrophin Triggers Myocardial Hypertrophy and Heart Failure in Transgenic Mice
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2004-05-07)Cardiac hypertrophy and heart failure remain leading causes of death in the United States. Many studies have suggested that, under stress, myocardium releases factors triggering protein synthesis and stimulating myocyte ...