Parames Chandra. Sil: Recent submissions
Now showing items 41-60 of 62
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Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway
(PERGAMON-ELSEVIER, 2008-12)The present study was conducted to investigate the role of arjunolic acid (AA) against sodium fluoride (NaF)-induced cytotoxicity and necrotic cell death in murine hepatocytes. Dose-dependent studies suggest that incubation ... -
Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-kappa B pathway: Role of a novel plant protein
(ELSEVIER IRELAND, 2009-01-27)Oxidative stress is a major cause of drug induced hepatic diseases. The present study aims to investigate the antioxidative signaling mechanism of a protein isolated from the herb, Cajanus indicus against acetaminophen ... -
A protein from Cajanus indicus Spreng protects liver and kidney against mercuric chloride-induced oxidative stress
(PHARMACEUTICAL SOC JAPAN, 2008-09)Mercuric chloride (HgCl(2)) is a widespread environmental toxin that affects mainly liver and kidney. The present stud), has been carried out to investigate the protective action of a protein (the CI protein) isolated from ... -
Taurine provides antioxidant defense against NaF-induced cytotoxicity in murine hepatocytes.
(ELSEVIER, 2008-10)Fluoride is an environmental and industrial pollutant that affects various organs in humans and animals. The present study was conducted to investigate the protective role of taurine (2-aminoethane sulphonic acid) against ... -
Prophylactic role of arjunolic acid in response to streptozotocin mediated diabetic renal injury: Activation of polyol pathway and oxidative stress responsive signaling cascades
(ELSEVIER IRELAND, 2009-10-30)Diabetic nephropathy is a common cause for end-stage renal disease. Present study investigated the beneficial role of arjunolic acid (AA) against streptozotocin (STZ) induced diabetic nephropathy in rats. Diabetic renal ... -
Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: Role of NF-kappa B, p38 and JNK MAPK pathway
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009-10-01)Cardiac dysfunction is a major cause of morbidity and mortality worldwide due to its complex pathogenesis. However, little is known about the mechanism of arsenic-induced cardiac abnormalities and the use of antioxidants ... -
Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection
(ELSEVIER SCIENCE, 2010-02-15)Acetaminophen (APAP) is a widely used analgesic and antipyretic drug and is safe at therapeutic closes but its overdose frequently causes liver injury. In earlier studies, we demonstrated that arjunolic acid (AA) has a ... -
Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: Therapeutic potential of arjunolic acid
(ELSEVIER IRELAND, 2010-01-31)Acetaminophen (APAP) causes acute and chronic renal failure. The mechanisms leading to hepatic injury have been extensively studied, but the molecular mechanisms regarding APAP-induced nephro-toxicity are poorly defined. ... -
Induction of necrosis in cadmium-induced hepatic oxidative stress and its prevention by the prophylactic properties of taurine
(ELSEVIER GMBH, 2009-11)The present study has been carried out to investigate the protective role of taurine against cadmium (Cd)-induced oxidative impairment in murine liver. Oral administration of cadmium chloride (CdCl(2)) at a dose of 4mg/kg ... -
Purification and characterisation of a novel antioxidant protein molecule from Phyllanthus niruri
(ELSEVIER SCI, 2009-06-15)The herb Phyllanthus niruri is known to possess antioxidant activity, but the nature of the responsible active principle(s) is not well defined. The present study reports the purification and characterisation of a 35 kDa ... -
Prophylactic role of taurine on arsenic mediated oxidative renal dysfunction via MAPKs/NF-B and mitochondria dependent pathways
(TAYLOR & FRANCIS, 2009)The present study has been designed and carried out to investigate the protective role of taurine (2-aminoethanesulphonic acid) against NaAsO2 induced nephrotoxicity. Oral administration of arsenic increased the productions ... -
Taurine protects rat testes against NaAsO2-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways
(ELSEVIER IRELAND, 2009-06-22)Arsenic (As) is a well known toxicity inducer. Recent investigations, however, showed that it might have some therapeutic application in cancer treatment. These dual roles of arsenic have attracted a renewed research in ... -
Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation
(ELSEVIER IRELAND, 2010-02-28)Acute exposure of acetaminophen (APAP), a widely used analgesic and antipyretic drug, causes severe renal damage and no specific agent has been reported so far that plays any beneficial role in this organ pathophysiology. ... -
Arsenic-induced oxidative cerebral disorders: Protection by taurine
(TAYLOR & FRANCIS, 2009-04)The present study was conducted to investigate whether the conditionally essential amino acid, taurine, could play any protective role against the potent neurotoxin arsenic (As)-induced oxidative impairment in the rat ... -
Acetaminophen induced acute liver failure via oxidative stress and JNK activation: Protective role of taurine by the suppression of cytochrome P450 2E1
(TAYLOR & FRANCIS, 2010-03)The present study was carried out to investigate whether taurine plays any beneficial role in acetaminophen (APAP)-induced acute hepatotoxicity. APAP exposure increased the plasma levels of ALT, ALP, LDH, TNF-alpha and NO ... -
Protective effect of the fruits of Terminalia arjuna against cadmium-induced oxidant stress and hepatic cell injury via MAPK activation and mitochondria dependent pathway
(ELSEVIER SCI LTD, 2010-12-15)Cadmium (Cd), a highly toxic environmental pollutant, induces hepatic disorders. The present study has been undertaken to investigate the protective role of the fruit extract of Terminalia arjuna (AE) against Cd-induced ... -
Hepatotoxicity of di-(2-ethylhexyl)phthalate is attributed to calcium aggravation, ROS-mediated mitochondrial depolarization, and ERK/NF-kappa B pathway activation
(ELSEVIER SCIENCE INC, 2010-12-01)Di-(2-ethylhexyl)phthalate (DEHP) is a widely used plasticizer found in a variety of polyvinyl chloride medical products. Although DEHP-induced cytotoxicity and apoptosis are well studied in various cell types, the precise ... -
Prevention of tertiary butyl hydroperoxide induced oxidative impairment and cell death by a novel antioxidant protein molecule isolated from the herb, Phyllanthus niruri
(PERGAMON-ELSEVIER SCIENCE, 2010-09)The present study has been designed and carried out to investigate the mechanism of the protective action of a novel antioxidant protein molecule, isolated from the herb, Phyllanthus niruri (PNP), against tertiary butyl ... -
Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid
(ELSEVIER SCIENCE INC, 2010-06-01)Diabetic mellitus, a chronic metabolic disorder, is one of the most important health problems in the world, especially in developing countries. Our earlier investigations reported the beneficial action of arjunolic acid ... -
Protective Role of Taurine against Arsenic-Induced Mitochondria-Dependent Hepatic Apoptosis via the Inhibition of PKC delta-JNK Pathway
(PUBLIC LIBRARY SCIENCE, 2010-09-07)Background: Oxidative stress-mediated hepatotoxic effect of arsenic (As) is mainly due to the depletion of glutathione (GSH) in liver. Taurine, on the other hand, enhances intracellular production of GSH. Little is known ...