Browsing Shubhra Ghosh Dastidar by Title

Now showing items 1-2 of 2

    • Moleculardynamicssimulations of Aβfibrilinteractions with β-sheetbreakerpeptides 

      Bruce, Neil J.; Chen, Deliang; Dastidar, Shubhra Ghosh; Marks, Gabriel E.; Schein, Catherine H.; Bryce, Richard A. (ELSEVIER SCIENCE, 2010-11)
      Accumulation and aggregation of the 42-residue amyloid-β (Aβ) protein fragment, which originates from the cleavage of amyloid precursor protein by β and γ secretase, correlates with the pathology of Alzheimer's disease ...

    • Role of Protein Flexibility in the Discovery of New Drugs 

      Fuentes, Gloria; Dastidar, Shubhra Ghosh; Madhumalar, Arumugam; Verma, Chandra S. (WILEY-BLACKWELL, 2011-02)
      Proteins have inherent flexibility, and this plays a critical role in a vast array of biological functions, including ligand binding. Structure-based drug design (SBDD) strategies incorporate biomolecular structures with ...