Department of Molecular Medicine -- (Formerly Animal Physiology before 2007): Recent submissions
Now showing items 41-60 of 219
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Preventive and curative role of a 43 kD protein from the leaves of the herb Cajanus indicus L on thioacetamide-induced hepatotoxicity in vivo
(ELSEVIER IRELAND LTD, 2005-09-01)An approximately 43 kD protein has been isolated and purified from the herb Cajanus indicits L and believed to be the most active principle for its hepatoprotective action. In this study, experiments have been performed ... -
Regulation of myotrophin gene by pressure overload and stretch
(KLUWER ACADEMIC PUBL, 2004-07-01)Hemodynamic load is a major determinant of cardiac mass and its phenotype, but very little is known about how mechanical load is converted into intracellular signals of gene expression and regulation. We have shown earlier ... -
Cardiac Overexpression of Myotrophin Triggers Myocardial Hypertrophy and Heart Failure in Transgenic Mice
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2004-05-07)Cardiac hypertrophy and heart failure remain leading causes of death in the United States. Many studies have suggested that, under stress, myocardium releases factors triggering protein synthesis and stimulating myocyte ... -
Regulation of impaired protein kinase C signaling by chemokines in murine macrophages during visceral leishmaniasis
(AMER SOC MICROBIOLOGY, 2005-12)The protein kinase C (PKC) family regulates macrophage function involved in host defense against infection. In the case of Leishmania donovani infection, the impairment of PKC-mediated signaling is one of the crucial events ... -
The Bcl-2 transgene protects T cells from renal cell carcinoma-mediated apoptosis
(AMER ASSOC CANCER RESEARCH, 2003-08-15)Purpose: Tumors induce T-cell apoptosis as a mechanism. of inhibiting antitumor immunity. Using coculture experiments, it has been shown that tumor lines stimulate T-cell apoptosis by a pathway involving a mitochondrial ... -
Alterations in air-sac and skeleton of triploid Heteropneustes fossilis
(BLACKWELL PUBLISHING LTD, 2004-01)Triploid stinging catfish Heteropneustes fossilis, when produced by cold shock, showed abnormalities in their air-sacs and skeletons. -
Putative L-triiodothyronine receptors in the liver nuclei of mature tropical toad, Bufo melanostictus
(VERLAG Z NATURFORSCH, 2004-01)Thyroid hormones exert a major role in growth and differentiation of almost all types of tissues in animals, particularly in amphibian metamorphosis, through its specific nuclear receptor activation followed by gene ... -
Stimulation of AChE activity in relation to changes in electron microscopic structure of adult rat cerebrocortical synaptosomes pretreated with 3-5-3 '-triiodo-L-thyronine
(LIPPINCOTT WILLIAMS & WILKINS, 2003-08-06)Triiodothyronine (T-3) stimulated AChE activity in depolarization-induced intact synaptosomes (isolated from adult rat cerebral cortex) suspended in calcium-supplemented choline chloride buffer in a time-dependent manner ... -
The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties
(JOHN WILEY & SONS LTD, 2006-07-01)The aim of this study was to investigate the hepatoprotective action of the protein fraction of Phyllanthus niruri against acetaminophen (APAP) hepatotoxicity. The partially purified protein fraction of P. niruri was ... -
A 43-kDa protein from the leaves of the herb Cajanus indicus L. modulates chloroform induced hepatotoxicity in vitro
(Informa Healthcare., 2006-12-01)A 43-kDa protein isolated from the leaves of the herb Cajanus indicus L. has been shown to possess a protective role against drug- and toxin- induced hepatotoxicity both in vivo and in vitro . The current study was conducted ... -
Over-expressed IgG2 antibodies against O-acetylated sialoglycoconjugates incapable of proper effector functioning in childhood acute lymphoblastic leukemia
(OXFORD UNIV PRESS, 2005-02)Earlier studies have demonstrated an over-expression of 9-O-acetylated sialoglycoconjugates (9-OAcSGs) on lymphoblasts, concomitant with high titers of anti-9-OAcSGs in childhood acute lymphoblastic leukemia (ALL). The ... -
Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo
(ELSEVIER, 2006-10-01)Nimesulide (NIM), an atypical non-steroidal anti-inflammatory drug (NSAID) is also used as analgesic. In the present study, we evaluated its effect on the prooxidant-antioxidant system of liver and the hepatoprotective ... -
Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders
(ELSEVIER, 2006-09-01)Background: Carbon tetrachloride (CCI4) is a well-known hepatotoxin and exposure to this chemical is known to induce oxidative stress and causes liver injury by the formation of free radicals. Acute and chronic renal damage ... -
Protein isolate from the herb, Phyllanthus niruri, protects liver from acetaminophen induced toxicity
(ELSEVIER, 2006-01-01)Phyllanthus niruri L. (Euphorbiaceae) is a well-known hepatoprotective herbal plant. The aim of this study was to investigate the hepatoprotective action of the protein isolate of Phyllanthus niruri (P. niruri) against ... -
Black tea protects thymocytes in tumor-bearing animals by differential regulation of intracellular ROS in tumor cells and thymocytes
(BEGELL HOUSE INC, 2005)The accumulated in vitro evidence indicates that many tumors induce T-cell apoptosis as a mechanism of inhibiting antitumor activity. This downregulation of cell-mediated immune functions occurring at the late stages of ... -
Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress.
(ELSEVIER, 2006-05-01)Present study was conducted to evaluate the role of a protein fraction (PI, protein isolate) of the herb, Phyllanthus niruri (P. niruri) against nimesulide-induced oxidative stress in vivo using a murine model. Mice were ... -
Tumor-induced dysfunction in T lymphocytes: increased sensitivity to apoptosis
(SPRINGER, 2004-09) -
A 43 kDa protein from the herb Cajanus indicus L. protects thioacetamide induced cytotoxicity in hepatocytes
(PERGAMON-ELSEVIER SCIENCE LTD, 2006-08-01)The aim of this study was to investigate the role of a hepatoprotective protein isolated from the herb Cajanus indicus L. on thioacetamide (TAA) induced toxicity in isolated mouse hepatocytes. In vitro cell viability, ... -
Effect of renal cell carcinomas on the development of type 1 T-cell responses( Conference Paper )
(AMER ASSOC CANCER RESEARCH, 2004-09-15)Purpose: We reported that in renal cell carcinoma patients with active disease, T-cell reactions to the tumor-associated antigens MAGE-6 and EphA2 are highly skewed toward T(H)2-type cytokine responses [interleukin (IL) ... -
Purification and characterization of a 43 kD hepatoprotective protein from the herb Cajanus indicus L.
(SPRINGER, 2006-09-01)Cajanus indicus L, a herb, is popularly known for its hepatoprotective activity. Aqueous extract of the leaves of this plant contains hepatoprotective and hepatostimulatory molecule(s). Present study was aimed to isolate, ...