Department of Molecular Medicine -- (Formerly Animal Physiology before 2007): Recent submissions
Now showing items 61-80 of 219
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Protective role of Phyllanthus niruri against nimesulide induced hepatic damage
(ELSEVIER, 2007)Present study aimed to evaluate the protective role of the aqueous extract of Phyllanthus niruri (P. niruri) against nimesulide-induced hepatic disorder in mice by determining levels of glutamate oxaloacetate transaminase ... -
Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio
(ELSEVIER SCI IRELAND LTD, 2004-06-25)It is known that cancer is associated with altered immune function. We demonstrated earlier that black tea inhibits tumor growth in a dose-dependent manner. Here, we report that apoptosis was the cause of immunocyte death ... -
Protein isolate from the herb Phyllanthus niruri modulates carbon tetrachloride-induced cytotoxicity in hepatocytes
(TAYLOR & FRANCIS INC, 2007-01-01)Phyllanthus niruri is a well-known hepatoprotective herbal plant. In the present study, hepatoprotective potential of the protein isolate of P. niruri was investigated against carbon tetrachloride (CCl4)-induced hepatoxicity ... -
P27 expression is regulated by separate signaling pathways, downstream of Ras, in each cell cycle phase
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-11-01)The cyclin inhibitory protein p27Kip1 (p27) plays a vital role in regulating cell proliferation in response to the extracellular growth environment. Active proliferation requires the suppression of p27 levels throughout ... -
Galactosamine-induced hepatotoxic effect and hepatoprotective role of a protein isolated from the herb Cajanus indicus L in vivo
(JOHN WILEY & SONS INC, 2007)D(+)-Galactosamine is a well-known experimental hepatotoxin. The present study was conducted to determine the protective role of a 43-kD protein isolated from the leaves of the herb Cajanus indices L against D(+)-galactosamine ... -
The biology of triploid fish
(SPRINGER, 2004-12)This review deals with major areas of triploidy research in fish. It includes not only methods for induction and detection of triploidy but also the impact of triploidy on morphology, anatomy, growth, haematology, energetics, ... -
Stimulation of Mg2+-independent form of Ca2+-ATPase by a low molecular mass protein purified from goat testes cytosol
(ELSEVIER SCIENCE INC, 2007-01-01)A low molecular mass protein purified from goat (Capra hircus) testes cytosol following gel filtration and anion exchange chromatographic separation stimulates Mg2+-independent Ca2+-ATPase activity without any significant ... -
Cloning and functional expression of an acyl-ACP thioesterase FatB type from Diploknema (Madhuca) butyracea seeds in Escherichia coli (M-T- 2006)
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2006-12-01)A cDNA of fatty acyl-acyl carrier protein (ACP) thioesterase (Fat) from developing seed of Madhuca butyracea has been cloned. The deduced amino acid sequence of the cDNA corresponding to the mature polypeptide showed 30-40% ... -
Regulation of Mg2+-independent Ca2+-ATPase by a low molecular mass protein purified from bovine brain
(IOS PRESS, 2006)he goat sperm microsomal membranes have been found to contain an Mg2+-independent Ca2+-ATPase, a low affinity but highly active enzyme sharing similarities with the SERCA family of ATPases. The present study reports the ... -
Black tea induces tumor cell apoptosis by Bax translocation, loss in mitochondrial transmembrane potential, cytochrome c release and caspase activation
(WILEY-LISS, DIV JOHN WILEY & SONS INC, 2005-11-01)Recently the anti-cancer role of black tea has gained immense importance. Nevertheless, the signaling pathways underlying black tea-induced tumor cell death are still unknown. Previously we reported that black tea induces ... -
Failure in peripheral immuno-surveillance due to thymic atrophy: Importance of thymocyte maturation and apoptosis in adult tumor-bearer(M-T-2005)
(PERGAMON-ELSEVIER SCIENCE LTD, 2005-10-07)Tumor-induced immunosuppression often leads to failure in cancer therapy. Here, in an attempt to understand the course of tumor-dependent immunosuppression in young adult murine model, we found that in Ehrlich's ascites ... -
Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin
(ELSEVIER SCI LTD, 2005)Background: The true therapeutic benefit of the use of natural products, especially acceptable dietary components such as curcumin, which can spare the normal cells and boost host immunity, has opened new horizons in cancer ... -
The regulation of S phase initiation by p27Kip1 in NIH3T3 cells
(LANDES BIOSCIENCE, 2005-04)Most eukaryotic cells become committed to divide once DNA synthesis begins. This critical event is controlled in yeast and Xenopus oocytes by the degradation of cyclin inhibitory proteins, while in mammalian cells ... -
Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G(2) phase of cell cycle in a p53-dependent manner
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2005-05-20)Curcumin (diferuloylmethane) is known to induce apoptosis in tumor cells. In asynchronous cultures, with time-lapse video-micrography in combination with quantitative fluorescence microscopy, we have demonstrated that ... -
Tumor-induced thymic involution via inhibition of IL-7R alpha and its JAK-STAT signaling pathway: Protection by black tea
(ELSEVIER SCIENCE BV, 2006-03)Down-regulation of cell-mediated immune functions occurring at late stages of cancer may be related to the thymic involution since thymus is the major site of T cell maturation, proliferation, and differentiation. We found ... -
Thyroid hormone profile during annual reproductive cycle of diploid and triploid catfish, Heteropneustes fossilis (Bloch)
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2006-06)Triploid fishes generally show sterility along with retarded gonadal development and aneuploid gametes. In teleosts, thyroid hormones influence seasonal adaptations and annual events such as reproduction. In addition, ... -
Specific and randomly derived immunoactive peptide mimotopes of mycobacterial antigens
(AMER SOC MICROBIOLOGY, 2006-10)The mycobacterial cell surface contains complex nonprotein antigens that are highly immunoactive in nature. However, these antigens are chemically heterogeneous and structurally complex, thereby limiting their applications. ... -
An unusual pro-inflammatory role of interleukin-10 induced by arabinosylated lipoarabinomannan in murine peritoneal macrophages
(SPRINGER, 2006-12)Various species of Mycobacteria produce a major cell wall-associated lipoglycan, called Lipoarabinomannan (LAM), which is involved in the virulence of Mycobacterial species. In this study, we tried to establish the role ... -
Lymph node cells from BALB/c mice with chronic visceral leishmaniasis exhibiting cellular anergy and apoptosis: Involvement of Ser/Thr phosphatase
(SPRINGER, 2006-11)Visceral leishmaniasis (VL) produced in BALB/c mice through intracardial administration of Leishmania donovani amastigotes was accompanied by hepatosplenomegaly with high organ parasite load and lymphadenopathy when followed ... -
GM2 expression in renal cell carcinoma: Potential role in tumor-induced T-cell dysfunction
(AMER ASSOC CANCER RESEARCH, 2006-07-01)Multiple mechanisms have been proposed to account for immune escape by tumors. Although gangliosides have long been known to suppress T-cell immunity, few studies have examined the effect of human tumor-derived gangliosides ...