Department of Molecular Medicine -- (Formerly Animal Physiology before 2007): Recent submissions
Now showing items 81-100 of 219
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Overcoming drug-resistant cancer by a newly developed copper chelate through host-protective cytokine-mediated apoptosis
(AMER ASSOC CANCER RESEARCH, 2006-07-15)Purpose: Previously, we have synthesized and characterized a novel Cu(II) complex, copper N-(2-hydroxyacetophenone) glycinate (CuNG). Herein, we have determined the efficacy of CuNG in overcoming multidrug-resistant cancer ... -
Immunosuppression, hepatotoxicity and depression of antioxidant status by arecoline in albino mice
(ELSEVIER IRELAND LTD, 2006-10-03)Background: There are about 600 million betel quid chewers in the world. Betal quid chewing is one of the major risk factors of hepatocarcinoma, oropharyngeal and esophagus cancers. Arecoline, the main Areca alkaloid of ... -
Maintenance of brain thyroid hormone level during peripheral hypothyroid condition in adult rat
(PERGAMON-ELSEVIER SCIENCE LTD, 2006-09-05)Thyroid hormones are essential for normal functioning of adult mammalian brain. The present investigation deals with the understanding of the time course of thyroid hormone homeostasis in adult rat brain. Animals were ... -
Alterations in enzyme activities in vital organs of triploid female catfish Heteropneustes fossilis (Bloch)
(SPRINGER, 2006-03)Triploid Heteropneustes fossilis (Bloch) showed sterility and higher growth potential than the normal diploid fish. Activities of some metabolic enzymes such as cytosolic NADP-malate dehydrogenase (NADP-MDH), mitochondrial ... -
Estradiol-17 beta: Tracing its metabolic significance in female fatbody of fifth instar larvae of silkworm, Bombyx mori L (race : Nistari)
(PERGAMON-ELSEVIER SCIENCE LTD, 2007-01-09)In recent years, various vertebrate peptide and steroid hormones have been identified in invertebrates, estradiol-17 beta (E-2) being a major one. We have specifically shown NADP-malate dehydrogenase (NADP-MDH) activity ... -
Induction of host protective th1 immune response by chemokines in Leishmania donovani-infected BALB/c mice
(BLACKWELL, 2007-12)The resolution from leishmanial infection is dependent on the coordinated interactions between the components of the cell mediated immune system and the activation of T-cell population into appropriate cytokine production ... -
Immunomodulatory role of arabinosylated lipoarabinomannan on Leishmania donovani infected murine macrophages
(NATL INST SCIENCE COMMUNICATION, 2007-10)Arabinosylated lipoarabinomannan (Ara-LAM), a surface glycolipid antigen isolated from avirulent Mycobacterium smegmatis is involved in modulation of host cell signaling. In this study, we investigated Ara-LAM-mediated ... -
Leishmania donovani-induced ceramide as the key mediator of Akt dephosphorylation in murine macrophages: Role of protein kinase C zeta and phosphatase
(AMER SOC MICROBIOLOGY, 2007-05)Leishmania donovani is an intracellular protozoan parasite that impairs the host macrophage immune response to render it suitable for its survival and establishment. L. donovani-induced immunosuppression and alteration of ... -
Tumor-induced oxidative stress perturbs nuclear factorr-kappa B activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: Protection by curcumin
(AMER ASSOC CANCER RESEARCH, 2007-01-01)Cancer patients often exhibit loss of proper cell-mediated immunity and reduced effector T-cell population in the circulation. Thymus is a major site of T-cell maturation, and tumors induce thymic atrophy to evade cellular ... -
TNF-alpha induction of GM2 expression on renal cell carcinomas promotes T cell dysfunction
(AMER ASSOC IMMUNOLOGISTS, 2007-05-15)Previous studies from our laboratory demonstrated the role of tumor-derived gangliosides as important mediators of T cell apoptosis, and hence, as one mechanism by which tumors evade immune destruction. In this study, we ... -
Black tea-induced decrease in IL-10 and TGF-ss of tumor cells promotes Th1/Tc1 response in tumor bearer.
(LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS, 2007)Several lines of evidence support that impairment of host immune function by tumor may be related to several strategies of tumor escape from immunosurveillance. We found that in Ehrlich's ascites carcinoma (EAC)-bearing ... -
Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2007-06-01)Patients with advanced cancer exhibit multifaceted defects in their immune capacity, which are likely to contribute to an increased susceptibility to infections and disease progression. We demonstrated earlier that curcumin ... -
Black tea-induced amelioration of hepatic oxidative stress through antioxidative activity in EAC-bearing mice
(BEGELL HOUSE INC, 2007)It is recognized that during cancer, the disease itself as well as many of the anticancer drugs in use produce undesirable side effects such as hepatotoxicity. We have already demonstrated the antitumor and immunorestoring ... -
Renal cell carcinoma tumors induce T cell apoptosis through receptor-dependent and receptor-independent pathways(M-T-ANR-2007-08)
(2008-04-01)Tumors can promote their own progressive growth by inducing T cell apoptosis. Though previous studies suggested that tumor-mediated T cell killing is receptor dependent, we recently showed that tumor gangliosides also ... -
Aqueous extract of the bark of Terminalia arjuna plays a protective role against sodium-fluoride-induced hepatic and renal oxidative stress
(SPRINGER TOKYO, 2007)Fluoride is an environmental and industrial pollutant. It has already been reported that the accumulation of fluoride can alter the activities of some enzymes involved in the free-radical metabolism and also decrease the ... -
A 43 kD protein from the herb, Cajanus indicus L., protects against fluoride induced oxidative stress in mice erythrocytes
(ELSEVIER, 2007-05-31)Present study has been carried out to evaluate the protective and curative roles of a 43 kD protein isolated from the herb Cajanus indicus L. on sodium fluoride (NaF) induced toxicity in mice erythrocytes. In the preventive ... -
Amelioration of galactosamine-induced nephrotoxicity by a protein isolated from the leaves of the herb, Cajanus indicus L.
(ELSEVIER, 2007-04-25)BACKGROUND: Galactosamine (GalN), an established experimental toxin, mainly causes liver injury via the generation of free radicals and depletion of UTP nucleotides. Renal failure is often associated with end stage liver ... -
Protection of arsenic-induced hepatic disorder by arjunolic acid
(BLACKWELL, 2007-11)Arsenic is one of the ubiquitous environmental pollutants, which affects nearly all organ systems. The present study has been carried out to investigate the hepatoprotective role of arjunolic acid, a triterpenoid saponin, ... -
A 43 kD protein isolated from the herb Cajanus indicus L attenuates sodium fluoride-induced hepatic and renal disorders in vivo
(SPRINGER, 2007-05-31)The herb, Cajanus indicus L, is well known for its hepatoprotective action. A 43 kD protein has been isolated, purified and partially sequenced from the leaves of this herb. A number of in vivo and in vitro studies carried ... -
Attenuation of acetaminophen-induced hepatotoxicity in vivo and in vitro by a 43-kD protein isolated from the herb Cajanus indicus L
(TAYLOR & FRANCIS INC, 2007-08)The aim of this study was to evaluate the hepatoprotective role of a 43-kD protein (Hp-P) isolated from the leaves of Cajanus indicus L. against acetaminophen (APAP)-induced toxicity in mouse liver and in isolated hepatocytes. ...