Department of Molecular Medicine -- (Formerly Animal Physiology before 2007): Recent submissions
Now showing items 101-120 of 219
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Phytomedicinal activity of Terminalia arjuna against carbon tetrachloride induced cardiac oxidative stress.
(ELSEVIER, 2007-10)Chronic and acute overproduction of reactive oxygen species (ROS) plays a positive role in the development of cardiovascular diseases under pathophysiological conditions. However, very little is known about carbon tetrachloride ... -
Attenuation of cadmium chloride induced cytotoxicity in murine hepatocytes by a protein isolated from the leaves of the herb Cajanus indicus L.
(SPRINGER, 2007-06)Cadmium has been recognized as a strong environmental pollutant. Exposure to this heavy metal occurs through the intake of foodstuffs, drinking water and also via the inhalation of air. Present study was conducted to ... -
Taurine, a conditionally essential amino acid, ameliorates arsenic-induced cytotoxicity in murine hepatocytes
(PERGAMON-ELSEVIER, 2007-12)Arsenic is a potent environmental toxin. Present study has been designed to evaluate the protective role of taurine (2-aminoethane-sulfonic acid) against arsenic induced cytotoxicity in murine hepatocytes. Sodium arsenite ... -
Anti-oxidative effect of a protein from Cajanus indicus L against acetaminophen-induced hepato-nephro toxicity
(SPRINGER SINGAPORE, 2007-11-30)Overdoses of acetaminophen cause hepato-renal oxidative stress. The present study was undertaken to investigate the protective effect of a 43 kDa protein isolated from the herb Cajanus indicus, against acetaminophen-induced ... -
Arjunolic acid, a triterpenoid saponin, ameliorates arsenic-induced cyto-toxicity in hepatocytes
(ELSEVIER, 2007-12-15)Arsenic is a well-established environmental toxin, which damages various organs of the body. A triterpenoid saponin, arjunolic acid (AA) has been isolated from the bark of Terminalia arjuna. The present study was conducted ... -
Hepatocytes are protected by herb Phyllanthus niruri protein isolate against thioacetamide toxicity.
(ELSEVIER, 2007-10)The herb, Phyllanthus niruri has been known to possess protective activity against various drugs and toxins induced hepatic disorders. Present study was conducted to evaluate the role of the protein isolate of the herb ... -
Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain
(JOHN WILEY & SONS INC, 2008)Arsenic, a notoriously poisonous metalloid, is ubiquitous in the environment, and it affects nearly all organ systems of animals including humans. The present study was designed to investigate the preventive role of a ... -
Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid
(SPRINGER, 2008-03)Arsenic, one of the most harmful metalloids, is ubiquitous in the environment. The present study has been carried out to investigate the protective role of a triterpenoid saponin, arjunolic acid (AA) against arsenic-induced ... -
Protection of arsenic-induced testicular oxidative stress by arjunolic acid
(MANEY PUBLISHING, 2008-04)Arsenic-induced tissue damage is a major concern to the human population. An impaired antioxidant defense mechanism followed by oxidative stress is the major cause of arsenic-induced toxicity, which can lead to reproductive ... -
Purification of protein from a crude mixture through SDS-PAGE transfer method
(NATL INST SCIENCE COMMUNICATION,, 2007-04)SDS-polyacrylamide gel electrophoresis (SDS-PAGE) transfer method was used for purification and enrichment of the protein from crude sample. Coomassie bluc/ZnSO4 stained protein band(s) containing intact polyacrylamide gel ... -
Maintenance of homeostasis for thyroid hormone in the adult rat brain: Possible involvement of a nuclear-mediated phenomenon
(KARGER, 2007)During adult-onset peripheral hypothyroidism, the brain maintains normal levels of thyroid hormone for some time through a mechanism of 'central homeostasis'. Although onset, duration, and termination of such a homeostatic ... -
Variations in hepatic estradiol-17 beta receptor concentrations during the annual reproductive cycle of diploid and triploid female catfish, Heteropneustes fossilis (Bloch)
(PERGAMON-ELSEVIER SCIENCE LTD, 2007-04-17)Concentrations of hepatic estradiol-17 beta (E2) receptors (ER) in cytosolic and nuclear fractions were evaluated in diploid and triploid female catfish Heteropneustes fossilis (Bloch) during four different reproductive ... -
Odorless regioselctive ring opening of epoxides with S-alkylisothiouronium salts as masked thiols in water
(ARKAT USA INC, 2009)Opening of epoxides with various S-alkylisothiouronium salts as thiol equivalent in water has been carried out in excellent yield following an environmentally benign odorless reaction condition. Yields were excellent in ... -
Facile synthesis of a tetrasaccharide corresponding to the capsular polysaccharide of Streptococcus pneumoniae type 15B
(ARKAT USA INC, 2009)A convergent synthetic approach is presented for the straightforward synthesis of the tetrasaccharide fragment of the capsular polysaccharide of Streptococcus pneumoniae type 15B. Coupling of a disaccharide thioglycoside ... -
Total synthesis of a unique tetrasaccharide present in the human clotting factor IX and mammalian Notch 1 receptor
(PERGAMON-ELSEVIER SCIENCE, 2009-03-11)The Synthesis Of a unique tetrasaccharide linked to the serine 61 of human clotting factor IX through an alpha-L-fucose residue has been achieved for the first time in excellent yield. All glycosylation and protecting group ... -
Syntheses and evaluation of glucosyl aryl thiosemicarbazide and glucosyl thiosemicarbazone derivatives as antioxidant and anti-dyslipidemic agents
(PERGAMON-ELSEVIER SCIENCE, 2009-01-15)A series of N-per-O-acetyl-glucosyl arylthiosemicarbazide and thiosemicarbazone derivatives have been synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Among 16 compounds ... -
Thyroid Hormone Homeostasis in Brain: Possible Involvement of Adrenergic Phenomenon in Adult Rat
(KARGER, 2009)Background: Imbalance in thyroid hormone concentrations has been linked with profound neurobehavioral alterations in the adult. Peripheral hypothyroidism is associated with a phenomenon of central thyroid hormone homeostasis ... -
Anti cancer effects of curcumin: cycle of life and death
(BIOMED CENTRAL, 2008)Increasing knowledge on the cell cycle deregulations in cancers has promoted the introduction of phytochemicals, which can either modulate signaling pathways leading to cell cycle regulation or directly alter cell cycle ... -
Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis
(SPRINGER, 2008-06)Theaflavins, the bioactive flavonoids of black tea, have been demonstrated to inhibit proliferation and induce apoptosis in a variety of cancer cells. However, the contribution of p53 in mammary epithelial carcinoma cell ... -
Terminalia arjuna Protects Mouse Hearts Against Sodium Fluoride-Induced Oxidative Stress
(MARY ANN LIEBERT INC, 2008-12)Fluoride is a ubiquitous environmental pollutant. In the current study we have investigated the antioxidative properties of an ethanol extract of the bark of Terminalia arjuna (T. arjuna ethanol extract [TAEE]) against ...