Department of Molecular Medicine -- (Formerly Animal Physiology before 2007): Recent submissions
Now showing items 121-140 of 219
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Taurine protects the antioxidant defense system in the erythrocytes of cadmium treated mice
(KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY, 2008-09-30)The present study was undertaken to investigate the protective role of taurine (2-aminoethanesulfonic acid) against cadmium (Cd) induced oxidative stress in murine erythrocytes. Cadmium chloride (CdCl2) was chosen as the ... -
Cadmium-induced neurological disorders: prophylactic role of taurine
(JOHN WILEY & SONS, 2008-11)The present study was conducted to investigate whether the conditionally essential amino acid taurine could play any protective role against the potent neurotoxin cadmium (Cd)-induced oxidative impairment in mice brain. ... -
Arjunolic acid attenuates arsenic-induced nephrotoxicity
(ELSEVIER, 2008-10)Arsenic is highly toxic naturally occurring element that affects numerous organ systems in humans. Present study was designed to investigate the preventive role of a triterpenoid saponin, arjunolic acid (AA) against ... -
Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis
(SPRINGER, 2012-05)The protective effect of taurine against doxorubicin-induced testicular oxidative stress and apoptosis was investigated in rats. Male rats 8 weeks of age were treated with doxorubicin alone (3 mg/kg, i.p. every other day ... -
Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction
(SPRINGER, 2009-03)The present study has been carried out to investigate the role of taurine (2-aminoethanesulfonic acid), a conditionally essential amino acid, in ameliorating cadmium-induced renal dysfunctions in mice. Cadmium chloride ... -
Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways
(ELSEVIER IRELAND, 2009-03-04)Increasing evidences in both experimental and clinical studies suggest that oxidative stress is involved in the pathogenesis of diabetic tissue damage. Pancreatic P-cell death is the cause of decreased insulin production ... -
Amelioration of cadmium-induced cardiac impairment by taurine
(ELSEVIER IRELAND, 2008-07-30)The present study has been designed to investigate the protective role of taurine (2-aminoethanesulfonic acid), a sulfur containing conditionally essential amino acid, against cadmium-induced cardiac dysfunction in mice. ... -
Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway
(PERGAMON-ELSEVIER, 2008-12)The present study was conducted to investigate the role of arjunolic acid (AA) against sodium fluoride (NaF)-induced cytotoxicity and necrotic cell death in murine hepatocytes. Dose-dependent studies suggest that incubation ... -
Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-kappa B pathway: Role of a novel plant protein
(ELSEVIER IRELAND, 2009-01-27)Oxidative stress is a major cause of drug induced hepatic diseases. The present study aims to investigate the antioxidative signaling mechanism of a protein isolated from the herb, Cajanus indicus against acetaminophen ... -
A protein from Cajanus indicus Spreng protects liver and kidney against mercuric chloride-induced oxidative stress
(PHARMACEUTICAL SOC JAPAN, 2008-09)Mercuric chloride (HgCl(2)) is a widespread environmental toxin that affects mainly liver and kidney. The present stud), has been carried out to investigate the protective action of a protein (the CI protein) isolated from ... -
Taurine provides antioxidant defense against NaF-induced cytotoxicity in murine hepatocytes.
(ELSEVIER, 2008-10)Fluoride is an environmental and industrial pollutant that affects various organs in humans and animals. The present study was conducted to investigate the protective role of taurine (2-aminoethane sulphonic acid) against ... -
Characterization of a low-molecular-mass stimulator protein of Mg2+-independent Ca2+-ATPase: effect on phosphorylation/dephosphorylation, calcium transport and sperm-cell motility
(PORTLAND PRESS, 2008-04)A 14 kDa cytosolic protein purified from bovine brain homogenate has been recently reported as a stimulator of goat spermatozoa Mg2+-independent Ca2+-ATPase. In the present study, we demonstrate the formation of the ... -
Localization and expression of a 70 kDa protein in goat spermatozoa having Na+,K+-ATPase inhibitory and arylsulphatase A activities
(SPRINGER, 2009-01)We have previously isolated and purified a goat sperm protein of 70 kDa molecular weight designated as P70 and characterized it as an inhibitor of Na+,K+-ATPase. Our study reveals that the first 10 amino acid residues from ... -
Anti-inflammatory effect of allylpyrocatechol in LPS-induced macrophages is mediated by suppression of iNOS and COX-2 via the NF-kappa B pathway
(ELSEVIER SCIENCE BV, 2008-09)The crude ethanol extract of Piper betle leaf is reported to possess anti-inflammatory activity which has been suggested to be mediated by allylpyrocatechol (APC). In the present study, we have demonstrated the anti-inflammatory ... -
Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function
(NATURE PUBLISHING GROUP, 2009-03)CD40, a costimulatory molecule expressed on macrophages, induces expression of interleukin 12 (IL-12) in uninfected macrophages and IL-10 in macrophages infected with Leishmania major. IL-12 suppresses, whereas IL-10 ... -
Arabinosylated lipoarabinomannan modulates the impaired cell mediated immune response in Mycobacterium tuberculosis H37Rv infected C57BL/6 mice
(ELSEVIER SCIENCE BV, 2008-04)Mycobacterium tuberculosis is a facultative intracellular pathogen that flourishes inside the host macrophages. This organism has the ability to deactivate the cell-mediated immune responses involving the down-regulation ... -
Restoration of impaired free radical generation and proinflammatory cytokines by MCP-1 in mycobacterial pathogenesis
(BLACKWELL PUBLISHING, 2008-04)Mycobacterium tuberculosis exerts its pathogenic effects mainly via its cell wall glycolipid called Mannosylated Lipoarabinomannan (Man-LAM), which subverts the cellular inflammatory responses by the suppression of superoxide ... -
Potentiation by cigarette smoke of macrophage function against Leishmania donovani infection
(BIRKHAUSER VERLAG AG, 2009-01)Cigarette smoke is able to induce the generation of reactive oxygen species and pro-inflammatory cytokines, which are mediators of macrophage function and therefore, we have investigated the ability of cigarette smoke to ... -
In Vitro Nicotine-Induced Oxidative Stress in Mice Peritoneal Macrophages: A Dose-Dependent Approach
(TAYLOR & FRANCIS INC, 2009-02)The immune cells use reactive oxygen species (ROS) for carrying out their normal functions while an excess amount of ROS can attack cellular components that lead to cell damage. In the present study, peritoneal macrophages ... -
A novel approach to regulate experimental visceral leishmaniasis in murine macrophages using CCR5 siRNA
(BLACKWELL PUBLISHING, 2008-04)Early infection with Leishmania donovani during visceral leishmaniasis (VL) results in the enhanced expression of C-C chemokine receptor 5 (CCR5) in macrophages. CCR5 expression at different time points of infection revealed ...