Department of Molecular Medicine -- (Formerly Animal Physiology before 2007): Recent submissions
Now showing items 141-160 of 219
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A Microsatellite DNA Marker Developed for Identifying Disease-resistant Population of Giant Black Tiger Shrimp, Penaeus monodon
(WILEY-BLACKWELL, 2009-04)White spot disease caused by white spot syndrome virus (WSSV) poses major problems that result in huge economic losses each year in shrimp aquaculture throughout the world. In the present study, microsatellite-based DNA ... -
Antioxidant and free radical scavenging activity of Spondias pinnata
(BIOMED CENTRAL, 2008-12-09)Background: Many diseases are associated with oxidative stress caused by free radicals. Current research is directed towards finding naturally-occurring antioxidants of plant origin. The aim of the present study was to ... -
Association of low-density lipoprotein particle size and ratio of different lipoproteins and apolipoproteins with coronary heart disease
(ELSEVIER, 2008-10)Background: Worldwide coronary heart disease (CHD) is estimated to be the leading cause of death. Current knowledge about prevention of CHD is mainly derived from developed countries. Therefore, this study aimed to find ... -
Current outlooks on the lipids of gastric membranes and beyond
(Research Trends, 2008)It has become increasingly clear in the recent years that the phospholipids and cholesterol are more functionally alive as the main building blocks of the bio-membranes than we previously thought. By virtue of its ability ... -
Regulation of tyrosine kinase activity during capacitation in goat sperm
(SPRINGER, 2010-03)Protein tyrosine phosphorylation is a key event accompanying sperm capacitation. Although this signaling cascade generates an array of tyrosine-phosphorylated polypeptides, their molecular characterization is still limited. ... -
Thyroid Hormone Homeostasis in Adult Mammalian Brain: A Novel Mechanism for Functional Preservation of Cerebral T3 Content During Initial Peripheral Hypothyroidism
(Dr.B.S.Patil, 2010)The essential role of thyroid hormone (TH) on the maturation and differentiation of the mammalian brain is well known. But the action of THs in the adult brain was not widely a focus of study by endocrinologists based ... -
GD3, an Overexpressed Tumor-Derived Ganglioside, Mediates the Apoptosis of Activated but not Resting T Cells
(AMER ASSOC CANCER RESEARCH, 2009-04-01)We previously elucidated an important role for gangliosides in renal cell carcinoma-mediated T lymphocyte apoptosis, although the mechanism by which they mediated lymphocyte death remained unclear. Here, we show that when ... -
Curcumin: From Exotic Spice to Modern Anticancer Drug
(Dr. B.S.Patil, 2010)Inhibition of defined molecular steps of tumourigenesis by natural non-toxic compounds may be an efficient means to tackle the population cancer burden. Extensive research has addressed the chemotherapeutic potential of ... -
Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells
(OXFORD UNIV PRESS, 2010-02)The most common alterations found in breast cancer are inactivation or mutation of tumor suppressor gene p53. The present study revealed that theaflavins induced p53-mutated human breast cancer cell apoptosis. Pharmacological ... -
A Novel Copper Chelate Modulates Tumor Associated Macrophages to Promote Anti-Tumor Response of T Cells
(PUBLIC LIBRARY SCIENCE, 2009-09-16)Background: At the early stages of carcinogenesis, the induction of tumor specific T cell mediated immunity seems to block the tumor growth and give protective anti-tumor immune response. However, tumor associated macrophages ... -
Tumor-shed PGE 2 impairs IL2Rγc-signaling to inhibit CD4 + T cell survival: Regulation by theaflavins
(PUBLIC LIBRARY SCIENCE, 2009-10-08)Background: Many tumors are associated with decreased cellular immunity and elevated levels of prostaglandin E2 (PGE2), a known inhibitor of CD4+ T cell activation and inducer of type-2 cytokine bias. However, the role of ... -
Eugenol protects nicotine-induced superoxide mediated oxidative damage in murine peritoneal macrophages in vitro
(ELSEVIER SCIENCE, 2009-11-25)The present work is aimed at evaluating the protective effect of eugenol against in vitro nicotine-induced toxicity in murine peritoneal macrophages, compared with N-acetylcysteine. Eugenol was isolated from Ocimum gratissimum ... -
Prophylactic role of arjunolic acid in response to streptozotocin mediated diabetic renal injury: Activation of polyol pathway and oxidative stress responsive signaling cascades
(ELSEVIER IRELAND, 2009-10-30)Diabetic nephropathy is a common cause for end-stage renal disease. Present study investigated the beneficial role of arjunolic acid (AA) against streptozotocin (STZ) induced diabetic nephropathy in rats. Diabetic renal ... -
Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: Role of NF-kappa B, p38 and JNK MAPK pathway
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009-10-01)Cardiac dysfunction is a major cause of morbidity and mortality worldwide due to its complex pathogenesis. However, little is known about the mechanism of arsenic-induced cardiac abnormalities and the use of antioxidants ... -
Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection
(ELSEVIER SCIENCE, 2010-02-15)Acetaminophen (APAP) is a widely used analgesic and antipyretic drug and is safe at therapeutic closes but its overdose frequently causes liver injury. In earlier studies, we demonstrated that arjunolic acid (AA) has a ... -
Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: Therapeutic potential of arjunolic acid
(ELSEVIER IRELAND, 2010-01-31)Acetaminophen (APAP) causes acute and chronic renal failure. The mechanisms leading to hepatic injury have been extensively studied, but the molecular mechanisms regarding APAP-induced nephro-toxicity are poorly defined. ... -
Induction of necrosis in cadmium-induced hepatic oxidative stress and its prevention by the prophylactic properties of taurine
(ELSEVIER GMBH, 2009-11)The present study has been carried out to investigate the protective role of taurine against cadmium (Cd)-induced oxidative impairment in murine liver. Oral administration of cadmium chloride (CdCl(2)) at a dose of 4mg/kg ... -
Purification and characterisation of a novel antioxidant protein molecule from Phyllanthus niruri
(ELSEVIER SCI, 2009-06-15)The herb Phyllanthus niruri is known to possess antioxidant activity, but the nature of the responsible active principle(s) is not well defined. The present study reports the purification and characterisation of a 35 kDa ... -
Prophylactic role of taurine on arsenic mediated oxidative renal dysfunction via MAPKs/NF-B and mitochondria dependent pathways
(TAYLOR & FRANCIS, 2009)The present study has been designed and carried out to investigate the protective role of taurine (2-aminoethanesulphonic acid) against NaAsO2 induced nephrotoxicity. Oral administration of arsenic increased the productions ... -
Taurine protects rat testes against NaAsO2-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways
(ELSEVIER IRELAND, 2009-06-22)Arsenic (As) is a well known toxicity inducer. Recent investigations, however, showed that it might have some therapeutic application in cancer treatment. These dual roles of arsenic have attracted a renewed research in ...