Department of Molecular Medicine -- (Formerly Animal Physiology before 2007): Recent submissions
Now showing items 161-180 of 219
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Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation
(ELSEVIER IRELAND, 2010-02-28)Acute exposure of acetaminophen (APAP), a widely used analgesic and antipyretic drug, causes severe renal damage and no specific agent has been reported so far that plays any beneficial role in this organ pathophysiology. ... -
Arsenic-induced oxidative cerebral disorders: Protection by taurine
(TAYLOR & FRANCIS, 2009-04)The present study was conducted to investigate whether the conditionally essential amino acid, taurine, could play any protective role against the potent neurotoxin arsenic (As)-induced oxidative impairment in the rat ... -
Acetaminophen induced acute liver failure via oxidative stress and JNK activation: Protective role of taurine by the suppression of cytochrome P450 2E1
(TAYLOR & FRANCIS, 2010-03)The present study was carried out to investigate whether taurine plays any beneficial role in acetaminophen (APAP)-induced acute hepatotoxicity. APAP exposure increased the plasma levels of ALT, ALP, LDH, TNF-alpha and NO ... -
Characterization of arylsulphatase A in a 70 kDa protein isolated from goat spermatozoa having Na+, K+-ATPase inhibitory activity
(NATL INST SCIENCE COMMUNICATION-NISCAIR, 2009-06)A protein having inhibitory effect on Na+, K+-ATPase as well as showing arylsulphatase A activity (ASA) was isolated from the cytosolic fraction of goat spermatozoa and characterized biochemically. The molecular mass of ... -
Assessment of in vitro antioxidant and free radical scavenging activity of Cajanus cajan
(The Berkeley Electronic Press, 2009-09)The present study was undertaken to evaluate the antioxidant and free radical scavenging activities of 70% methanolic extract of Cajanus cajan leaves using various in vitro assays. The TEAC value 0.84 ± 0.05 for the extract ... -
Evaluation of the in vitro antioxidant and iron chelating activity of Gymnema sylvestre
(University of Salerno, 2009-09)The study evaluated the in vitro antioxidant activity of 70% methanolic extract of Gymnema sylvestre leaves, which is was well known for its antidiabetic and sweet suppressing properties. The extract was used to determine ... -
Assessment of the Antioxidant and Reactive Oxygen Species Scavenging Activity of Methanolic Extract of Caesalpinia crista Leaf
(EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011)"Oxidative stress" is initiated by reactive oxygen species (ROS), which are responsible for majority of the diseases. However, antioxidants with ROS scavenging ability may have great relevance in the prevention of oxidative ... -
Studies on antioxidant and antiradical activities of Dolichos biflorus seed extract
(ACADEMIC JOURNALS, 2009-08-18)The antioxidant potential of 70% methanolic extract of Dolichos biflorus seeds was assessed using different tests including total antioxidant activity, hydroxyl radical scavenging, superoxide radical scavenging, nitric ... -
The antioxidant, iron chelating and DNA protective properties of 70% methanolic extract of 'katha' (heartwood extract of Acacia catechu)
(Berkeley Electronic Press, 2010-03)The present study was carried out to determine the antioxidant and iron chelating property of 70% methanolic extract of 'katha' (heartwood extract of Acacia catechu). The extract was found to be an antioxidant with a TEAC ... -
Relation of anti- to pro-inflammatory cytokine ratios with acute myocardial infarction
(Korean Journal of Internal Medicine, 2010-03)BACKGROUND/AIMS: Acute myocardial infarction (AMI) is a leading cause of death. Inflammatory processes play an important role in atherosclerosis, which is intimately related to AMI. The aim of this study was to investigate ... -
Synthesis of a Trisaccharide and a Tetrasaccharide from the Cell-Wall Lipopolysaccharides of Azospirillum brasilense S17
(GEORG THIEME VERLAG KG, 2009-08-03)A trisaccharide containing a D-mannosamine moiety and a tetrasaccharide containing an L-rhamman chain that are found in the cell walls of Azospirillum brasilense S17 were synthesized concisely and in excellent yields. The ... -
N-Bromosuccinimide-Mediated Conversion of Allyl Glycosides to Glycosyl Hemiacetals
(TAYLOR & FRANCIS, 2010-03)A novel reaction condition has been developed for the hydrolysis of differentially functionalized allyl glycosides to their corresponding glycosyl hemiacetal derivatives in the presence of N-bromosuccinimide (NBS). The ... -
Synthesis of Tri- and Disaccharide Fragments Related to the O-Antigen of Enteropathogenic Escherichia Coli O158
(TAYLOR & FRANCIS, 2010-01)Chemical synthesis of a tri- and a disaccharide related to the O-antigen of enteropathogenic E. coli O158 was achieved in high yield. In the disaccharide (2), one D-galactosamine unit is present in 1,2-cis-linked and the ... -
First synthesis of a pentasaccharide repeating unit of the O-antigenic polysaccharide from enterohaemorrhagic Escherichia coli O48:H21
(PERGAMON-ELSEVIER SCIENCE, 2009-07-16)A concise synthesis of a pentasaccharide as its 4-methoxyphenyl glycoside, found in the O-antigenic polysaccharide of enterohaemorrhagic Escherichia coli O48:H21 has been achieved for the first time in excellent yield. ... -
Synthesis of (6,6 ')-C-Linked Pseudodisaccharides
(TAYLOR & FRANCIS, 2009-11-25)A series of (6,6')-C-linked pseudodisaccharides has been prepared using a general synthetic strategy of olefin metathesis in the presence of Grubbs second-generation catalyst. Yields were excellent in every case. -
Efficient Synthesis of Two Sialylated Tetrasaccharides Found in Goat Milk
(GEORG THIEME VERLAG KG, 2009-04-17)Two regioisomeric sialylated tetrasaccharides found in goat milk have been obtained in excellent yield by a concise synthesis using a common disaccharide intermediate. Regioselective glycosylations and a minimal number of ... -
Total synthesis of the heptasaccharide repeating unit of the iron-binding exopolysaccharide secreted by Klebsiella oxytoca BAS-10
(PERGAMON-ELSEVIER SCIENCE, 2009-08-12)The first total synthesis of a heptasaccharide found in the iron-binding exopolysaccharide produced by Klebsiella oxytoca BAS-10 has been achieved in excellent yield using a block synthetic strategy. A trisaccharide glycosyl ... -
Synthesis of the Trisaccharide Repeat of the O-Antigen of Rhanella Aquatilis 1-95
(TAYLOR & FRANCIS, 2010-01)A branched trisaccharide containing D-fucose and D-galactofuranose moieties corresponding to the repeating unit of the O-antigen of Rahnella aquatilis 1-95 has been synthesized from the monosaccharide intermediates in a ... -
Anti-IL-10 mAb protection against experimental visceral leishmaniasis via induction of Th1 cytokines and nitric oxide
(NATL INST SCIENCE COMMUNICATION, 2009-06)Visceral leishmaniasis is characterized by severe immune suppression of the host. This suppression of the host immune system is primarily mediated by the immunosuppressive cytokine Interleukin-10 (IL-10), whose levels are ... -
Synthesis of a tetrasaccharide corresponding to the teichoic acid from the cell wall of Streptomyces sp VKM Ac-2275
(PERGAMON-ELSEVIER SCIENCE, 2009-12-11)A concise chemical synthesis of a tetrasaccharide found in the teichoic acid from the cell wall of Streptomyces sp. VKM Ac-2275 was achieved in high yield. A [2+2] block synthetic strategy has been adopted for the construction ...