Department of Molecular Medicine -- (Formerly Animal Physiology before 2007): Recent submissions
Now showing items 181-200 of 219
-
Concise Synthesis of a Hexasaccharide Related to the Adhesin Receptor of Streptococcus oralis ATCC 55229
(TAYLOR & FRANCIS, 2009-09)A concise synthesis of a hexasaccharide related to the adhesin receptor of Streptococcus oralis ATCC 55229 (previously characterized as Streptococcus sanguis H1) has been achieved in excellent yield. A general glycosylation ... -
CXC Chemokine-Mediated Protection against Visceral Leishmaniasis: Involvement of the Proinflammatory Response
(UNIV CHICAGO PRESS, 2009-10-15)Visceral leishmaniasis, caused by the protozoan parasite Leishmania donovani, is characterized by the loss of ability of the host to generate an effective immune response. In the present study, the comparative potential ... -
Multifocal signal modulation therapy of cancer: ancient weapon, modern targets
(SPRINGER, 2010-03)Although safe in most cases, ancient treatments are ignored because neither their active components nor their molecular targets are well defined. This is not the case, however, with curcumin, a yellow-pigment substance and ... -
Theaflavins retard human breast cancer cell migration by inhibiting NF-kappa B via p53-ROS cross-talk
(ELSEVIER SCIENCE, 2010-01-04)The present study demonstrates that theaflavins exploit p53 to impede metastasis in human breast cancer cells. Our data suggest that p53-dependent reactive oxygen species (ROS) induce p53-phosphorylation via p38MAPK in a ... -
Tumor-Shed PGE(2) Impairs IL2R gamma c-Signaling to Inhibit CD4(+) T Cell Survival: Regulation by Theaflavins
(PUBLIC LIBRARY SCIENCE, 2009-10-08)Background: Many tumors are associated with decreased cellular immunity and elevated levels of prostaglandin E2 (PGE2), a known inhibitor of CD4+ T cell activation and inducer of type-2 cytokine bias. However, the role of ... -
Synthesis of penta- and hexasaccharide fragments corresponding to the O-antigen of Escherichia coli O150
(PERGAMON-ELSEVIER SCIENCE, 2010-09-08)The chemical synthesis of a pentasaccharide and a hexasaccharide corresponding to the O-antigen of Escherichia coli O150 has been achieved using sequential glycosylation and [3+3] block glycosylation strategies. Suitably ... -
Efficient synthesis of (6-deoxy-glycopyranosid-6-yl) sulfone derivatives and their effect on Ca 2+-ATPase
(Elsevier Masson, 2010-12)Synthesis of a series of novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives has been achieved using a general synthetic strategy. Yields were excellent in every case. The synthetic compounds were evaluated for their ... -
Convergent synthesis of a common pentasaccharide corresponding to the O-antigen of Escherichia coli O168 and Shigella dysenteriae type 4
(SPRINGER, 2011-01-01)A convenient synthetic strategy of the common acidic pentasaccharide repeating unit corresponding to the O-antigen of enterotoxigenic E. coli O168 and Shigella dysenteriae type 4 has been successfully developed. A ... -
Synthesis of the hexasaccharide repeating unit corresponding to the cell wall lipopolysaccharide of Azospirillum irakense KBC1
(PERGAMON-ELSEVIER SCIENCE LTD, 2010-12-08)A convenient chemical synthesis of the hexasaccharide repeating unit of the cell wall lipopolysaccharide of Azospirillum irakense KBC1 has been successfully achieved. A stereo- and regioselective [4 + 2] block glycosylation ... -
Protective effect of the fruits of Terminalia arjuna against cadmium-induced oxidant stress and hepatic cell injury via MAPK activation and mitochondria dependent pathway
(ELSEVIER SCI LTD, 2010-12-15)Cadmium (Cd), a highly toxic environmental pollutant, induces hepatic disorders. The present study has been undertaken to investigate the protective role of the fruit extract of Terminalia arjuna (AE) against Cd-induced ... -
Hepatotoxicity of di-(2-ethylhexyl)phthalate is attributed to calcium aggravation, ROS-mediated mitochondrial depolarization, and ERK/NF-kappa B pathway activation
(ELSEVIER SCIENCE INC, 2010-12-01)Di-(2-ethylhexyl)phthalate (DEHP) is a widely used plasticizer found in a variety of polyvinyl chloride medical products. Although DEHP-induced cytotoxicity and apoptosis are well studied in various cell types, the precise ... -
Convergent synthesis of a common pentasaccharide-repeating unit corresponding to the O-specific polysaccharide of Escherichia coli O4:K3, O4:K6, and O4:K12
(PERGAMON-ELSEVIER SCIENCE, 2010-04-21)A convergent chemical synthesis of a pentasaccharide found in the O-specific polysaccharide of Escherichia coli O4:K3, O4:K6, and O4:K12 has been achieved in excellent yield. A [3+2] block synthetic strategy has been adopted ... -
Prevention of tertiary butyl hydroperoxide induced oxidative impairment and cell death by a novel antioxidant protein molecule isolated from the herb, Phyllanthus niruri
(PERGAMON-ELSEVIER SCIENCE, 2010-09)The present study has been designed and carried out to investigate the mechanism of the protective action of a novel antioxidant protein molecule, isolated from the herb, Phyllanthus niruri (PNP), against tertiary butyl ... -
Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid
(ELSEVIER SCIENCE INC, 2010-06-01)Diabetic mellitus, a chronic metabolic disorder, is one of the most important health problems in the world, especially in developing countries. Our earlier investigations reported the beneficial action of arjunolic acid ... -
Protective Role of Taurine against Arsenic-Induced Mitochondria-Dependent Hepatic Apoptosis via the Inhibition of PKC delta-JNK Pathway
(PUBLIC LIBRARY SCIENCE, 2010-09-07)Background: Oxidative stress-mediated hepatotoxic effect of arsenic (As) is mainly due to the depletion of glutathione (GSH) in liver. Taurine, on the other hand, enhances intracellular production of GSH. Little is known ... -
Efficient acylation and sulfation of carbohydrates using sulfamic acid, a mild, eco-friendly catalyst under organic solvent-free conditions
(ROYAL SOC CHEMISTRY, 2011-05)A fast and efficient acylation of carbohydrate derivatives and free sugars using a stoichiometric quantity of acylating agents in the presence of sulfamic acid, an environmentally benign catalyst, under organic solvent-free ... -
Gain of Cellular Adaptation Due to Prolonged p53 Impairment Leads to Functional Switchover from p53 to p73 during DNA Damage in Acute Myeloid Leukemia Cells
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2010-10-22)Although it has been well established that spermatogenic cells undergo apoptosis when treated with ethanol, the molecular mechanisms behind it remain to be investigated. Adult male mice were given intra-peritoneal injection ... -
Amphotericin B regulates the host immune response in visceral leishmaniasis: reciprocal regulation of protein kinase C isoforms.
(W B SAUNDERS, 2010-07)OBJECTIVES: Treatment of visceral leishmaniasis (VL) is marked by the failure of pentavalent antimonials which has brought amphotericin B (AmpB) to the forefront. In this study we have focused on signaling pathway ... -
Alteration of immune functions and Th1/Th2 cytokine balance in nicotine-induced murine macrophages: Immunomodulatory role of eugenol and N-acetylcysteine
(ELSEVIER SCIENCE, 2011-04)The aim of this study was to evaluate the immune functions by nicotine-induced murine peritoneal macrophages, and Th1/Th2 cytokine balance in it, and concurrently to establish the immunomodulatory role of eugenol, and ... -
Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts
(NATURE PUBLISHING GROUP, 2010-07-01)Immune dysfunction is well documented during tumor progression and likely contributes to tumor immune evasion. CD8(+) cytotoxic T lymphocytes (CTLs) are involved in antigen-specific tumor destruction and CD4(+) T cells are ...