Browsing Department of Biochemistry by Title
Now showing items 1-20 of 237
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310-Helix adjoining α-helix and β-strand: Sequence and structural features and their conservation
(WILEY-BLACKWELL, 2005-06-15)Does the amino acid use at the terminal positions of an α-helix become altered depending on the context-more specifically, when there is an adjoining 310-helix, and can a single helical cylinder encompass the resultant ... -
Accessibility and partner number of protein residues, their relationship and a webserver, ContPlot for their display
(BIOMED CENTRAL, 2009-04-08)Background: Depending on chemical features residues have preferred locations – interior or exterior – in protein structures, which also determine how many other residues are found around them. The close packing of residues ... -
Analysis of interactions in proteins and structural studies on a few proteins from Vibrio cholerae
(Bose Institute, Kolkata, 2006) -
Analysis of nonbonded interactions in protein structures
(Bose Institute, Kolkata, 2004) -
An analysis of protein-nucleic acid interactions and crystallization studies of proteins
(Bose Institute, Kolkata, 2008) -
Analysis of the nonbonded interactions and their implications in protein structure and function
(Bose Institute, Kolkata, 1999) -
Antagonistic effects Na＋ and Mg2＋ on the structure, function, and stability of mycobacteriophage L1 repressor
(KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY, 2009-05-31)Temperate mycobacteriophage L1 encodes an unusual repressor (CI) for regulating its lytic-lysogenic switching and, in contrast to the repressors of most temperate phages, it binds to multiple asymmetric operator DNAs. Here, ... -
Antagonists of Hsp16.3, a low-molecular-weight mycobacterial chaperone and virulence factor, derived from phage-displayed peptide libraries
(AMER SOC MICROBIOLOGY, 2005-11)The persistence of Mycobacterium tuberculosis is a major cause of concern in tuberculosis (TB) therapy. In the persistent mode the pathogen can resist drug therapy, allowing the possibility of reactivation of the disease. ... -
Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin
(JOHN WILEY & SONS, 2008-01)In this review, an attempt has been made to throw light on the mechanism of action of colchicine and its different analogs as anti-cancer agents. Colchicine interacts with tubulin and perturbs the assembly dynamics of ... -
Antibiotics, arsenate and H2O2 induce the promoter of Staphylococcus aureus cspC gene more strongly than cold
(WILEY-BLACKWELL, 2009-04)Proteins expressed by the bacterial cold shock genes are highly conserved at sequence level and perform various biological functions in both the cold-stressed and normal cells. To study the effects of various agents on the ... -
Antimicrotubular drugs binding to vinca domain of tubulin
(KLUWER ACADEMIC PUBL, 2003-11)Studies on vinca domain binding drugs were done in great details by a number of workers as it is recognized as a potential target for anticancer drug development. Their structures, properties, mode of action, success and ... -
Antimitotic drugs binding to tubulin: a calorimetric and spectroscopic study.
(Bose Institute, Kolkata, 2006) -
Antimitotic sulfonamides inhibit microtubule assembly dynamics and cancer cell proliferation
(AMER CHEMICAL SOC, 2006-08-01)Several sulfonamides have antitumor activities and are currently undergoing clinical evaluation for the treatment of cancer. In this study, we have elucidated the antiproliferative mechanism of action of five indole ... -
Autodigestion, proteolysis and structural studies of the Lambda cI repressor and investigation of its rec A-mediated cleavage
(Bose Institute, Kolkata, 2006) -
The B-ring substituent at C-7 of colchicine and the alpha-C-terminus of tubulin communicate through the "tail-body" interaction
(WILEY-LISS, 2004-11-15)The carboxy terminals of alphabeta-tubulins are flexible regions rich in acidic amino acid residues that play an inhibitory role in the polymerization of tubulin to microtubules. We have shown that the binding of colchicine ... -
The bacteriophage lambda DNA replication protein P inhibits the oriC DNA- and ATP-binding functions of the DNA replication initiator protein DnaA of Escherichia coli
(SPRINGER SINGAPORE PTE LTD, 2005-01-31)Under the condition of expression of ?, P protein at lethal level, the oriC DNA-binding activity is significantly affected in wild-type E. coli but not in the rpl mutant. In purified system, the 2, P protein inhibits the ... -
Binding of Indanocine to the Colchicine Site on Tubulin Promotes Fluorescence, and Its Binding Parameters Resemble Those of the Colchicine Analogue AC
(AMER CHEMICAL SOC, 2009-02-24)Indanocine, a synthetic indanone, has shown potential antiproliferative activity against several tumor types. It is different from many other microtubule-disrupting drugs, because it displays toxicity toward multidrug ... -
Biochemical studies on tubulin-Microtubule system(with reference to avian erythrocycles).
(Bose Institute, Kolkata, 1979) -
BioSuite: A comprehensive bioinformatics software package (A unique industry-academia collaboration)
(CURRENT SCIENCE ASSN, 2007-01-10)