Department of Biochemistry: Recent submissions
Now showing items 41-60 of 237
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Interresidue contacts in proteins and protein-protein interfaces and their use in characterizing the homodimeric interface
(AMER CHEMICAL SOC, 2005-09)The environment of amino acid residues in protein tertiary structures and three types of interfaces formed by protein-protein association-in complexes, homodimers, and crystal lattices of monomeric proteins-has been analyzed ... -
Structure of λ CII: Implications for recognition of direct-repeat DNA by an unusual tetrameric organization
(NATL ACAD SCIENCE, 2005-08-09)The temperate coliphage X, after infecting its host bacterium Escherichia coli, can develop either along the lytic or the lysogenic pathway. Crucial to the lysis/lysogeny decision is the homo tetrameric transcription-activator ... -
Constitutive association of Mcm2-3-5 proteins with chromatin in Entamoeba histolytica
(BLACKWELL PUBLISHING LTD, 2005-02)Eukaryotic cells duplicate their genome once and only once per cell cycle. Our earlier studies with the protozoan parasite, Entamoeba histolytica, have shown that genome reduplication may occur several times without nuclear ... -
Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence
(ELSEVIER SCIENCE BV, 2005-12-19)Caloric restriction (CR) is the most compelling example of lifespan extension by external manipulation. Although the molecular mechanisms remain unknown, the theory of hormesis has been invoked to explain the life promoting ... -
The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005-11-11)We show that the budding yeast protein Chl1p, required for sister-chromatid cohesion, also modulates transcriptional silencing at HMR and telomeres. The absence of this protein results in increased silencing at HMR and, ... -
Antagonists of Hsp16.3, a low-molecular-weight mycobacterial chaperone and virulence factor, derived from phage-displayed peptide libraries
(AMER SOC MICROBIOLOGY, 2005-11)The persistence of Mycobacterium tuberculosis is a major cause of concern in tuberculosis (TB) therapy. In the persistent mode the pathogen can resist drug therapy, allowing the possibility of reactivation of the disease. ... -
The G23 and G25 genes of temperate mycobacteriophage L1 are essential for the transcription of its late genes
(SPRINGER SINGAPORE PTE LTD, 2007-03-31)Two lysis-defective but DNA synthesis non-defective temperature-sensitive (is) mutants of mycobacteriophage L1, L1G23ts23 and L1G25ts889 were found to be defective also in phage-specific RNA synthesis in the late period ... -
Studies on synonymous codon and amino acid usage biases in the broad-host range bacteriophage KVP40(M-T-2007)
(MICROBIOLOGY SOC KOREA, 2007-02)In this study, the relative synonymous codon and amino acid usage biases of the broad-host range phage, KVP40, were investigated in an attempt to understand the structure and function of its proteins/proteincoding genes, ... -
Effects of physical, ionic, and structural factors on the binding of repressor of mycobacteriophage L1 to its cognate operator DNA
(BENTHAM SCIENCE PUBL LTD, 2006)To determine the factors influencing the binding of L1 repressor to its cognate operator DNA, several gel shift as well as bioinformatic analyses have been carried out. The data show that time, temperature, salt, and pH ... -
Factors influencing synonymous codon and amino acid usage biases in Mimivirus
(ELSEVIER SCI LTD, 2006-08)Synonymous codon and amino acid usage biases have been investigated in 903 Mimivirus protein-coding genes in order to understand the architecture and evolution of Mimivirus genome. As expected for an AT-rich genome, third ... -
Leishmanial proteins can correct human mitochondrial mutations
(INDIAN ACADEMY SCIENCES, 2006-12) -
Eh Klp5 is a divergent member of the kinesin 5 family that regulates genome content and microtubular assembly in Entamoeba histolytica
(WILEY-BLACKWELL, 2007-02)Earlier studies have established two unusual features in the cell division cycle of Entamoeba histolytica. First, microtubules form a radial assembly instead of a bipolar mitotic spindle, and second, the genome content of ... -
EhRho1, a RhoA-like GTPase of Entamoeba histolytica, is modified by clostridial glucosylating cytotoxins
(AMER SOC MICROBIOLOGY, 2006-12)Clostridial glucosylating cytotoxins inactivate mammalian Rho GTPases by mono-O glucosylation of a conserved threonine residue located in the switch 1 region of the target protein. Here we report that EhRho1, a RhoA-like ... -
Parity in the number of atoms in residue composition in proteins and contact preferences
(CURRENT SCIENCE ASSN, 2006-02-25)Two ways of looking into the amino acid composition in a database - one based on counting residues and another on the number of atoms each residue contributes to the total - give quite different results. In the former, the ... -
The budding yeast protein Chl1p is required to preserve genome integrity upon DNA damage in S-phase
(OXFORD UNIV PRESS, 2006-11)The budding yeast protein, Chl1p, is required for sister-chromatid cohesion, transcriptional silencing, rDNA recombination and aging. In this work, we show that Chl1p is also required for viability when DNA replication is ... -
Antimitotic sulfonamides inhibit microtubule assembly dynamics and cancer cell proliferation
(AMER CHEMICAL SOC, 2006-08-01)Several sulfonamides have antitumor activities and are currently undergoing clinical evaluation for the treatment of cancer. In this study, we have elucidated the antiproliferative mechanism of action of five indole ... -
Oxalone and lactone moieties of podophyllotoxin exhibit properties of both the B and C rings of colchicine in its binding with tubulin
(AMER CHEMICAL SOC, 2006-05-23)Thermodynamics of podophyllotoxin binding to tubulin and its multiple points of attachment with tubulin has been studied in detail using isothermal titration calorimetry. The calorimetric enthalpy of the association of ... -
BioSuite: A comprehensive bioinformatics software package (A unique industry-academia collaboration)
(CURRENT SCIENCE ASSN, 2007-01-10) -
Enhanced stability of cis Pro-Pro peptide bond in Pro-Pro-Phe sequence motif
(ELSEVIER, 2007-09-18)dentification of sequence motifs that favor cis peptide bonds in proteins is important for understanding and designing proteins containing turns mediated by cis peptide conformations. From H-1 NMR solution studies on short ... -
Detection of antistaphylococcal and toxic compounds by biological assay systems developed with a reporter Staphylococcus aureus strain harboring a heat inducible promoter - lacZ transcriptional fusion
(SPRINGER SINGAPORE PTE LTD, 2007-11-30)Previously it was reported that promoter of groES-groEL operon of Staphylococcus aureus is induced by various cellwall active antibiotics. In order to exploit the above promoter for identifying novel antistaphylococcal ...